Med18 Activators
Med18 Activators are a collection of chemical compounds that are believed to influence the function of Med18, a protein critical in signal transduction as part of the Mediator complex. These activators, including Methylprednisolone, Dexamethasone, Triamcinolone, Prednisone, Fludrocortisone, Betamethasone, Hydrocortisone, Prednisolone, Cortisone, Deflazacort, Mometasone, and Ciclesonide, are all glucocorticoid receptor (GR) agonists. The Mediator complex, which includes Med18, is responsible for transducing signals from the GR to RNA polymerase II, a crucial process in gene expression. By acting as agonists to the GR, these compounds can amplify the signal transduction process in which Med18 is directly involved, thereby enhancing its functional activity.
Each of these Med18 Activators has a unique interaction with the GR. For instance, Prednisone is a prodrug that is converted in the body to Prednisolone, a direct GR agonist. In contrast, Ciclesonide is also a prodrug, but it is converted in the body to des-ciclesonide, another GR agonist. Regardless of their individual mechanisms, all of these compounds share the ability to enhance the GR to RNA polymerase II signal transduction process, thereby amplifying the functional activity of Med18.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methylprednisolone | 83-43-2 | sc-205749 sc-205749A | 100 mg 500 mg | $117.00 $265.00 | 1 | |
Methylprednisolone is a glucocorticoid receptor (GR) agonist. Med18 is part of the Mediator complex, which plays a crucial role in transducing signals from the GR to RNA polymerase II. By activating the GR, Methylprednisolone can enhance the signal transduction process where Med18 is directly involved, leading to enhanced Med18 activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a GR agonist. Med18, as part of the Mediator complex, is directly involved in signal transduction from the GR to RNA polymerase II. Activation of the GR by Dexamethasone can thus enhance Med18's functional activity in this signal transduction process. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $42.00 $136.00 $676.00 | 2 | |
Prednisone is a prodrug that is converted in the body to prednisolone, a GR agonist. Med18 is part of the Mediator complex, which is involved in transducing signals from the GR to RNA polymerase II. By activating the GR, Prednisone can lead to an enhanced signal transduction process where Med18 is directly involved. | ||||||
Fludrocortisone | 127-31-1 | sc-207690 | 50 mg | $454.00 | ||
Fludrocortisone is a synthetic GR agonist. Med18, being part of the Mediator complex, is directly involved in signal transduction from the GR to RNA polymerase II. Therefore, activation of the GR by Fludrocortisone can enhance Med18's functional activity. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone is a GR agonist. Med18 is part of the Mediator complex, playing a role in transducing signals from the GR to RNA polymerase II. Hydrocortisone, by activating the GR, can enhance Med18's functional activity in signal transduction. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $84.00 $253.00 | 2 | |
Prednisolone is a GR agonist. Med18, being a part of the Mediator complex, plays a role in transducing signals from the GR to RNA polymerase II. Activation of the GR by Prednisolone can enhance the signal transduction process where Med18 is directly involved. | ||||||
Cortisone | 53-06-5 | sc-207455 | 5 g | $230.00 | ||
Cortisone is converted in the body to Hydrocortisone, a GR agonist. Med18, as a part of the Mediator complex, is involved in transducing signals from the GR to RNA polymerase II. By activating the GR, Cortisone can enhance Med18's functional activity in signal transduction. | ||||||
Deflazacort | 14484-47-0 | sc-204709C sc-204709 sc-204709A sc-204709B | 25 mg 100 mg 250 mg 1 g | $61.00 $194.00 $316.00 $1020.00 | ||
Deflazacort is a prodrug that is converted in the body to 21-desacetyldeflazacort, a GR agonist. Med18 is part of the Mediator complex, which transduces signals from the GR to RNA polymerase II. By activating the GR, Deflazacort can enhance the signal transduction process where Med18 is directly involved. | ||||||
Mometasone Furoate | 83919-23-7 | sc-211919 | 10 mg | $146.00 | ||
Mometasone is a GR agonist. Med18, as part of the Mediator complex, is involved in transducing signals from the GR to RNA polymerase II. By activating the GR, Mometasone can enhance Med18's functional activity in signal transduction. | ||||||
Ciclesonide | 126544-47-6 | sc-207432 | 10 mg | $205.00 | 2 | |
Ciclesonide is a prodrug that is converted in the body to des-ciclesonide, a GR agonist. Med18 is part of the Mediator complex, which is involved in transducing signals from the GR to RNA polymerase II. By activating the GR, Ciclesonide can enhance Med18's functional activity in signal transduction. | ||||||