Mdr-1 Inhibitors
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Items 11 to 20 of 21 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyrimethamine-d3 | 1189936-99-9 | sc-219678 | 1 mg | $330.00 | ||
Pyrimethamine-d3 exhibits a remarkable ability to modulate the Mdr-1 transporter by engaging in selective molecular interactions that facilitate its transport dynamics. The compound's isotopic labeling enhances its detection in biochemical assays, allowing for precise tracking of its influence on transporter activity. Its unique structural features promote specific electrostatic interactions and steric effects, which can significantly impact the kinetics of substrate efflux and the overall transport mechanism. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
Pyrimethamine demonstrates intriguing behavior as an Mdr-1 modulator through its ability to alter membrane permeability and influence substrate binding affinities. Its unique structural conformation allows for specific hydrogen bonding and hydrophobic interactions with the transporter, potentially affecting conformational changes. The compound's kinetic profile reveals a nuanced interplay between competitive inhibition and allosteric modulation, which can lead to variations in transport efficiency and substrate specificity. | ||||||
Niguldipine hydrochloride | 113317-61-6 | sc-201471 sc-201471A | 10 mg 50 mg | $79.00 $318.00 | ||
Niguldipine hydrochloride exhibits distinctive characteristics as an Mdr-1 modulator, primarily through its capacity to interact with lipid bilayers and alter membrane dynamics. Its unique stereochemistry facilitates specific electrostatic interactions with the transporter, influencing its conformational states. The compound's reaction kinetics suggest a complex mechanism involving both competitive and non-competitive inhibition, which may impact the transporter's substrate recognition and translocation efficiency. | ||||||
CP 100356 hydrochloride | 142716-85-6 | sc-361154 sc-361154A | 10 mg 50 mg | $370.00 $1100.00 | ||
CP 100356 hydrochloride demonstrates unique properties as an Mdr-1 modulator, characterized by its ability to disrupt protein-lipid interactions within cellular membranes. This compound engages in specific hydrogen bonding and hydrophobic interactions, which can stabilize or destabilize the transporter’s structure. Its kinetic profile indicates a nuanced interplay of binding affinities, potentially leading to altered substrate specificity and transport dynamics, thereby influencing cellular efflux mechanisms. | ||||||
Reversan | 313397-13-6 | sc-296262 sc-296262A | 10 mg 50 mg | $185.00 $781.00 | 3 | |
Reversan acts as a potent Mdr-1 modulator, exhibiting distinctive interactions with membrane proteins that alter their conformational states. It engages in specific electrostatic and van der Waals interactions, which can enhance or inhibit the activity of the transporter. The compound's unique reaction kinetics suggest a complex binding mechanism, potentially affecting the transporter's affinity for various substrates and modifying efflux pathways in cellular environments. | ||||||
PGP-4008 | 365565-02-2 | sc-222152 sc-222152A | 2 mg 10 mg | $107.00 $349.00 | 1 | |
PGP-4008 functions as a notable Mdr-1 modulator, characterized by its ability to disrupt typical substrate translocation through intricate molecular interactions. It engages in selective hydrogen bonding and hydrophobic interactions with the transporter, influencing its structural dynamics. The compound's unique kinetic profile indicates a multi-step binding process, which may alter the transporter's substrate specificity and efflux efficiency, thereby impacting cellular transport mechanisms. | ||||||
Elacridar | 143664-11-3 | sc-207613A sc-207613 sc-207613B sc-207613C sc-207613D | 5 mg 10 mg 50 mg 100 mg 1 g | $96.00 $111.00 $403.00 $515.00 $2555.00 | 19 | |
Elacridar inhibits MDR-1 by binding to P-glycoprotein and preventing drug efflux, enhancing drug delivery to target tissues. | ||||||
8-Isopentenylnaringenin | 68682-02-0 | sc-221146 | 5 mg | $326.00 | ||
8-Isopentenylnaringenin acts as a significant Mdr-1 modulator, exhibiting a unique capacity to alter transporter conformation through specific ligand-receptor interactions. Its distinct molecular architecture facilitates enhanced binding affinity, leading to competitive inhibition of substrate transport. The compound's influence on the allosteric sites of the transporter suggests a complex interplay of steric and electronic effects, potentially reshaping the efflux pathways and modulating cellular permeability. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Vismodegib functions as a notable Mdr-1 modulator, characterized by its ability to disrupt the normal transport dynamics of substrates. Its unique structural features enable it to engage in specific interactions with the transporter, promoting conformational changes that hinder substrate efflux. This compound's kinetic profile indicates a selective binding mechanism, influencing the transporter's activity and potentially altering the cellular microenvironment through modulation of efflux efficiency. | ||||||
Pyrimethamine Biotin | sc-219677 | 10 mg | $360.00 | |||
Pyrimethamine Biotin demonstrates a distinctive capacity to influence the Mdr-1 transporter through intricate binding dynamics that promote conformational changes. This compound interacts with key amino acid residues, enhancing the stability of the transporter’s substrate-binding site. Its unique chemical structure allows for specific hydrogen bonding and hydrophobic interactions, which modulate the transport efficiency and alter the kinetics of substrate translocation across cellular membranes. | ||||||