Molecular structure of Niguldipine hydrochloride, CAS Number: 113317-61-6
Niguldipine hydrochloride (CAS 113317-61-6)
Alternate Names:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Application:
Niguldipine hydrochloride is a selective α 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker
CAS Number:
113317-61-6
Molecular Weight:
646.18
Molecular Formula:
C36H39N3O6•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Niguldipine HCl has been reported to be a highly selective alpha 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker. More specifically, Niguldipine HCl may act to irreversibly inhibit T-type calcium channel currents in certain types of central and peripheral neurons and in smooth muscle cells. This compound has also been noted to inhibit noradrenaline-stimulated inositol phosphate accumulation. Additional reports demonstrate that Niguldipine HCl can potently and specifically inhibit bTREK-1 (IC50 = 5.07muM). Niguldipine HCl is an inhibitor of Mdr-1.
Niguldipine hydrochloride (CAS 113317-61-6) References
- Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. | Höllt, V., et al. 1992. Biochem Pharmacol. 43: 2601-8. PMID: 1352973
- Potent inhibition of native TREK-1 K+ channels by selected dihydropyridine Ca2+ channel antagonists. | Liu, H., et al. 2007. J Pharmacol Exp Ther. 323: 39-48. PMID: 17622574
- Trophic effects induced by alpha1D-adrenoceptors on endothelial cells are potentiated by hypoxia. | Vinci, MC., et al. 2007. Am J Physiol Heart Circ Physiol. 293: H2140-7. PMID: 17660397
- Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices. | Robinson, JP. and Kendall, DA. 1990. Br J Pharmacol. 100: 3-4. PMID: 2164859
- Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells. | Stengel, W., et al. 1998. Eur J Pharmacol. 342: 339-45. PMID: 9548406
Inhibitor of:
AR, Calcium Channel Protein, and Mdr-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Niguldipine hydrochloride, 10 mg | sc-201471 | 10 mg | $81.00 | |||
Niguldipine hydrochloride, 50 mg | sc-201471A | 50 mg | $324.00 |