MDA5 Inhibitors
MDA5 inhibitors represent a class of chemical compounds that specifically target and modulate the activity of the Melanoma Differentiation-Associated protein 5 (MDA5). MDA5 is a crucial component of the innate immune system, playing a pivotal role in detecting viral RNA and initiating antiviral responses within the host cell. This receptor is a member of the RIG-I-like receptor (RLR) family and is primarily responsible for recognizing long dsRNA molecules, which are often associated with viral infections. Upon activation, MDA5 triggers a cascade of signaling events that culminate in the production of type I interferons and proinflammatory cytokines, thereby coordinating the body's defense against viral pathogens. MDA5 inhibitors, as their name suggests, are designed to interfere with the normal functioning of MDA5, and as a result, can modulate the host immune response to viral infections.
The development of MDA5 inhibitors represents a promising area of research in the field of immunology. By selectively blocking the activity of MDA5, these compounds can influence the intensity and nature of the immune response mounted against invading viruses. This modulation could be leveraged for various purposes, such as exploring their effects on viral replication or understanding the nuances of the host-virus interaction. Additionally, these inhibitors might serve as valuable tools for investigating the intricate mechanisms underlying MDA5-mediated immunity, shedding light on the broader landscape of antiviral defense mechanisms in the human body. Understanding the structural and functional aspects of MDA5 inhibitors can provide valuable insights into the design of novel strategies and the development of innovative antiviral agents.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes. It may inhibit MDA5 expression by modulating various signaling pathways, including those involving antioxidants and anti-inflammatory responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, the main active component in turmeric, has anti-inflammatory and antioxidant properties. It may downregulate MDA5 expression through its effects on NF-κB and other signaling pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with anti-inflammatory and antioxidant activities. It may inhibit MDA5 expression by affecting various cellular signaling pathways, including the modulation of cytokine production. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It is known for its antioxidant and anti-inflammatory properties, potentially downregulating MDA5 expression through modulation of NF-κB activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is the main catechin in green tea. It has antioxidant and anti-inflammatory properties, which may contribute to its potential role in inhibiting MDA5 expression through various signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soybeans. It may inhibit MDA5 expression by modulating signaling pathways related to inflammation and cell survival. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
Silibinin is a compound found in milk thistle. It has antioxidant and anti-inflammatory effects, potentially inhibiting MDA5 expression by affecting various cellular processes and signaling pathways. | ||||||
Ferulic acid | 1135-24-6 | sc-204753 sc-204753A sc-204753B sc-204753C sc-204753D | 5 g 25 g 100 g 500 g 1 kg | $42.00 $62.00 $153.00 $552.00 $988.00 | 10 | |
Ferulic acid is found in plant cell walls. It possesses antioxidant and anti-inflammatory properties, potentially inhibiting MDA5 expression through modulation of signaling pathways. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol is a flavonoid with antioxidant and anti-inflammatory properties. It may downregulate MDA5 expression by affecting various signaling pathways involved in inflammation. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavonoid found in many fruits and vegetables. It has anti-inflammatory properties and may inhibit MDA5 expression through modulation of signaling pathways. | ||||||