MDA-7 Activators
The class of chemicals known as MDA-7 Activators encompasses a diverse range of compounds, primarily characterized by their ability to indirectly influence the activation of MDA-7, or Interleukin-24. These activators operate through various signaling pathways and cellular processes that are intricately linked to the functional regulation of MDA-7. Compounds like Curcumin and Resveratrol, known for their polyphenolic structure, modulate inflammatory responses and sirtuin activity, respectively, thereby influencing MDA-7 activation. Their actions are mediated through key pathways such as NF-κB and AMPK, which play a critical role in cellular stress responses and homeostasis.
The group also includes Sulforaphane, Quercetin, and Epigallocatechin Gallate (EGCG), each targeting different aspects of cellular signaling like Nrf2-mediated oxidative stress response, PI3K/Akt modulation, and JNK pathway influence. These mechanisms collectively contribute to the regulation of cellular processes that can lead to the activation of MDA-7. Other members like Berberine, Genistein, and Silibinin offer unique contributions through their influence on metabolic pathways, hormonal signaling, and cell growth regulation, respectively. Further, compounds such as Indole-3-Carbinol, Vitamin D3, Capsaicin, and Alpha-Lipoic Acid broaden the spectrum of this chemical class by targeting a range of processes from hormonal metabolism and immune response to sensory neuron signaling and oxidative stress modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A polyphenolic compound that can modulate various signaling pathways including NF-κB, potentially leading to the activation of MDA-7 through the modulation of inflammatory responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Influences sirtuin activity and the AMPK pathway, which are involved in cellular stress responses and may lead to MDA-7 activation due to the compound's role in regulating cellular homeostasis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
A compound found in cruciferous vegetables that can activate Nrf2, a regulator of oxidative stress response, potentially influencing MDA-7 activation through oxidative stress pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that modulates various signaling pathways including PI3K/Akt, which could lead to the activation of MDA-7 through alterations in cell survival and apoptosis pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major component of green tea that affects multiple signaling pathways including JNK, which might influence MDA-7 activation through stress response mechanisms. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
An alkaloid that modulates AMPK activity and influences metabolic pathways, potentially leading to MDA-7 activation through changes in cellular energy balance. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A soy isoflavone that modulates estrogen receptor signaling and related pathways, potentially influencing MDA-7 activation through hormonal signaling pathways. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
A flavonolignan from milk thistle that affects various signaling pathways including STAT3, potentially leading to MDA-7 activation through modulation of cell growth and apoptosis signaling. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Found in cruciferous vegetables, it modulates estrogen metabolism and may activate MDA-7 through alterations in hormonal signaling pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Influences calcium signaling and immune responses, potentially leading to MDA-7 activation through its role in immune modulation and cell differentiation. | ||||||