MDA-7 Antibody (Y14): sc-80184

MDA-7 Antibody (Y14) is a mouse monoclonal IgG2b kappa light chain antibody that detects MDA-7 protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-MDA-7 antibody (Y14) is available as the non-conjugated format. MDA-7, also known as melanoma differentiation associated protein-7 or IL-24, plays a crucial role in regulating cell growth and differentiation, particularly in melanoma cells. MDA-7 is secreted and can act in a paracrine manner, influencing neighboring cells and contributing to the tumor microenvironment. MDA-7 has been shown to induce apoptosis in cancer cells while sparing normal cells, making MDA-7 a potential therapeutic target for cancer treatment. MDA-7′s ability to modulate immune responses and promote tumor suppression underscores MDA-7′s importance in cancer biology. MDA-7′s unique structure, which includes a conserved IL-10-like domain, is essential for biological activity and interaction with specific receptors, further highlighting MDA-7′s significance in therapeutic applications.

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MDA-7 Antibody (Y14) References:

1. mda-7 In combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft.  |  Inoue, S., et al. 2007. Mol Ther. 15: 287-94. PMID: 17235306
2. Soluble human MDA-7/IL-24: characterization of the molecular form(s) inhibiting tumor growth and stimulating monocytes.  |  Mumm, JB., et al. 2006. J Interferon Cytokine Res. 26: 877-86. PMID: 17238830
3. MDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo.  |  Gopalan, B., et al. 2007. Mol Cancer. 6: 11. PMID: 17274815
4. Staphylococci induce the production of melanoma differentiation-associated protein-7/IL-24.  |  Buzas, K. and Megyeri, K. 2006. Acta Microbiol Immunol Hung. 53: 431-40. PMID: 17278711
5. [Mechanisms responsible for antitumor activity of melanoma differentiation-associated gene -7/interleukin-24].  |  Yang, M. and Qian, WB. 2007. Zhejiang Da Xue Xue Bao Yi Xue Ban. 36: 98-102. PMID: 17290500
6. The development of MDA-7/IL-24 as a cancer therapeutic.  |  Dent, P., et al. 2010. Pharmacol Ther. 128: 375-84. PMID: 20732354
7. Role of MDA-7/IL-24 a Multifunction Protein in Human Diseases.  |  Menezes, ME., et al. 2018. Adv Cancer Res. 138: 143-182. PMID: 29551126
8. MDA-7/interleukin 24 (IL-24) in tumor gene therapy: application of tumor penetrating/homing peptides for improvement of the effects.  |  Rasoolian, M., et al. 2019. Expert Opin Biol Ther. 19: 211-223. PMID: 30612497
9. Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells.  |  Fisher, PB., et al. 1985. J Interferon Res. 5: 11-22. PMID: 3989332
10. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.  |  Jiang, H., et al. 1995. Oncogene. 11: 2477-86. PMID: 8545104
11. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth.  |  Jiang, H., et al. 1996. Proc Natl Acad Sci U S A. 93: 9160-5. PMID: 8799171
12. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.  |  Su, ZZ., et al. 1998. Proc Natl Acad Sci U S A. 95: 14400-5. PMID: 9826712