MCM3AP Inhibitors
MCM3AP inhibitors refer to a class of chemical compounds that specifically target and inhibit the activity of the MCM3AP (Minichromosome Maintenance Complex Component 3 Associated Protein) gene product. MCM3AP is a protein that plays a role in the replication of genetic material by interacting with components of the DNA replication machinery. It is known to have an important function in the assembly of the minichromosome maintenance (MCM) complex, which is critical for the initiation of DNA replication. MCM3AP inhibitors, through their interaction with the protein, can modulate the biological processes that the MCM complex is involved in, specifically by impeding the proper assembly or function of the MCM complex, potentially affecting the replication fidelity or timing.
The action of MCM3AP inhibitors involves the precise molecular interaction with the protein to affect its function. These inhibitors are typically designed to bind to the MCM3AP protein in a way that disrupts its interaction with other components of the MCM complex. The binding is often highly specific, requiring the inhibitor to have a molecular structure that complements the binding site on the MCM3AP protein. This specificity is achieved through a detailed understanding of the protein's three-dimensional structure and the key domains involved in its activity. By binding to these critical regions, MCM3AP inhibitors can effectively halt the protein's ability to contribute to the MCM complex assembly, thereby influencing the overall process of DNA replication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
An inhibitor of DNA polymerase, can indirectly affect MCM3AP by inhibiting DNA synthesis, where MCM3AP plays a role. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, leads to decrease in deoxyribonucleotide pools, indirectly affecting DNA replication where MCM3AP is involved. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, causing DNA damage and potentially influencing the activity of MCM3AP at replication forks. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Targets DNA topoisomerase II, leading to DNA damage and indirectly affecting replication processes involving MCM3AP. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog causing DNA chain termination, could indirectly affect the function of MCM3AP in DNA replication. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Forms DNA crosslinks, potentially impacting the function of MCM3AP in DNA replication by altering the DNA structure. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Crosslinks DNA, similarly to Cisplatin, could indirectly affect MCM3AP involved in DNA replication. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor, can interfere with DNA repair processes, potentially influencing the role of MCM3AP in replication. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
CDK4/6 inhibitor, can interfere with cell cycle progression, potentially affecting MCM3AP function at the initiation of replication. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor, could alter chromatin structure and indirectly impact MCM3AP function in DNA replication. | ||||||