MCM2 Activators
MCM2 Activators represent a category of chemical compounds that influence the activity of the MCM2 protein. MCM2 is part of the minichromosome maintenance complex (MCM) that plays an essential role in DNA replication. The MCM complex, specifically MCM2-7, forms a helicase that unwinds DNA, making it an integral part of the replication process. The proper functioning and regulation of MCM2 and its associated proteins are crucial for maintaining the fidelity of DNA replication and ensuring genomic stability. Disturbances in the regular function of these proteins can lead to replication stress, where DNA synthesis may become problematic or even stall. By modulating the activity of MCM2, these activators can influence the dynamics of the DNA replication process.
The precise molecular mechanisms through which MCM2 Activators operate can vary based on their chemical structure and specific target sites on the MCM2 protein or its interacting partners. These activators might enhance the binding affinity of the MCM complex to DNA, promote its helicase activity, or stabilize its interactions with other essential replication proteins. Given the critical nature of DNA replication in cellular growth and division, understanding the intricacies of MCM2 activators is vital. Researchers study these compounds to gain deeper insights into DNA replication regulation, genomic stability, and cellular processes that rely on precise DNA duplication.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is involved in cellular differentiation. Its role may upregulate MCM2 expression as cells prepare for DNA replication during differentiation processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a phytoestrogen, may modulate cell proliferation, possibly leading to an increase in the demand for replication proteins like MCM2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cyclic AMP levels, which can affect cell cycle progression and potentially upregulate MCM2 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can alter chromatin structure and affect the expression of various genes, possibly including MCM2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, another histone deacetylase inhibitor, may modify chromatin, potentially leading to changes in the transcription of replication-related genes like MCM2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can inhibit DNA methylation. Demethylated DNA can lead to altered gene expression, potentially affecting the levels of MCM2. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, dexamethasone might influence cellular responses, including cell cycle regulation, possibly affecting MCM2 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, affecting cell growth and proliferation. This could lead to changes in the demand for replication machinery and potentially increase MCM2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to affect cell cycle progression and might influence the expression of genes related to DNA replication, such as MCM2. | ||||||