MCAT Activators
MCAT activators constitute a category of chemical agents designed to enhance the enzymatic activity of the mitochondrial acyl carrier protein (ACP) acyltransferase, commonly abbreviated as MCAT. This enzyme plays a critical role in the mitochondrial fatty acid synthesis (mtFAS) pathway, which is essential for maintaining the proper function of the mitochondrial respiratory chain through the production of lipoic acid and the maintenance of the cardiolipin content in mitochondrial membranes. MCAT is responsible for the transfer of acetyl groups to the acyl carrier protein within mitochondria, a pivotal step in the chain-elongation process of fatty acid synthesis.
The activation of MCAT by these chemical compounds can be achieved through several mechanisms. Direct activators may interact with the active site of the enzyme, promoting a conformational change that increases its catalytic efficiency or stabilizes the enzyme-substrate complex, thereby enhancing the transfer rate of the acetyl group to ACP. Indirect activators may exert their effects by upregulating the expression of the MCAT gene, altering the stability of MCAT mRNA, or modulating the post-translational modifications that can affect MCAT activity and stability. MCAT activators are valuable in research for exploring the dynamics of mitochondrial metabolism and the role of mtFAS in various cellular processes, including energy production, apoptosis, and mitochondrial biogenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-CoA participates in the biosynthesis of fatty acids where MCAT is involved. It serves as the starting point for the elongation of fatty acids, and its availability can indirectly activate MCAT by providing the necessary substrate. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Malonyl CoA is the substrate for MCAT in the fatty acid biosynthesis pathway. The presence of malonyl CoA can activate MCAT by providing the molecule required for its enzymatic function. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citrate can promote the production of Acetyl-CoA and Oxaloacetate via the TCA cycle, and Acetyl-CoA is a substrate for MCAT, indirectly activating it. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH provides the reducing equivalents for biosynthetic reactions including fatty acid biosynthesis where MCAT is involved. An increase in NADPH levels can indirectly activate MCAT by promoting the fatty acid biosynthesis process. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP provides the energy for many cellular processes including fatty acid biosynthesis. Higher ATP levels can indirectly activate MCAT by promoting its function in the fatty acid biosynthesis process. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose metabolism generates Acetyl-CoA which is a substrate for MCAT, thus glucose can indirectly activate MCAT by increasing the availability of its substrate. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin promotes glucose uptake and its subsequent metabolism which can increase the levels of Acetyl-CoA, a substrate for MCAT, thus indirectly activating MCAT. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvate is metabolized to Acetyl-CoA which is a substrate for MCAT, thus pyruvate can indirectly activate MCAT by increasing the availability of Acetyl-CoA. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine can indirectly activate MCAT by enhancing fatty acid oxidation, which can increase the demand for new fatty acid synthesis where MCAT plays a crucial role. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
Coenzyme A is required for the functioning of MCAT in fatty acid biosynthesis. Increased levels of Coenzyme A can indirectly activate MCAT by facilitating its function. | ||||||