MBD4 Activators
MBD4 Activators are a class of chemical compounds that can enhance the functional activity of MBD4, a DNA glycosylase involved in base excision repair (BER) of methylated DNA. The functional activity of MBD4 is enhanced when the demand for DNA repair is increased. This can be achieved by inducing DNA damage or replication stress. DNA damaging agents like cisplatin, etoposide, camptothecin, bleomycin, doxorubicin, and mitomycin C cause DNA lesions that require repair. This increases the demand for BER, the pathway where MBD4 functions, thereby enhancing its activity. Similarly, MNNG and MMS, which directly methylate DNA, increase the demand for MBD4 activity as it specifically repairs DNA by removing thymine or uracil from G:T mismatches caused by cytosine deamination.
Indirect activators of MBD4 include compounds that cause replication stress, like hydroxyurea and aphidicolin. These compounds inhibit DNA synthesis, leading to the accumulation of single-strand DNA breaks and an increased demand for DNA repair, thereby enhancing MBD4 activity. The DNA methyltransferase inhibitor, 5-Aza-2'-deoxycytidine, can also enhance MBD4 activity by causing DNA hypomethylation, which may increase the number of substrates for MBD4. Lastly, PARP inhibitors like olaparib can indirectly enhance MBD4 activity by causing the accumulation of single-strand breaks, which increases the demand for BER
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor that can lead to the accumulation of single-strand DNA breaks. This indirectly enhances MBD4 activity by increasing the demand for base excision repair, the pathway where MBD4 functions. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea is a ribonucleotide reductase inhibitor that causes replication stress and increases the demand for DNA repair, thereby potentially enhancing MBD4 activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a platinum-containing anticancer drug that forms DNA adducts. This can indirectly enhance MBD4 activity by increasing the demand for DNA repair. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a specific inhibitor of DNA polymerase α, δ, and ε, leading to replication stress and increased demand for DNA repair, thereby enhancing MBD4 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that causes DNA double-strand breaks and indirectly enhances MBD4 activity by increasing the demand for DNA repair. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA damage and indirectly enhances MBD4 activity by increasing the demand for DNA repair. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Bleomycin is a glycopeptide antibiotic that induces DNA double-strand breaks and indirectly enhances MBD4 activity by increasing the demand for DNA repair. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
MMS is an alkylating agent that directly methylates DNA, increasing the demand for MBD4 activity, which repairs DNA by removing thymine or uracil from G:T mismatches. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is a topoisomerase II inhibitor that induces DNA double-strand breaks and indirectly enhances MBD4 activity by increasing the demand for DNA repair. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is an alkylating agent that cross-links DNA, indirectly enhancing MBD4 activity by increasing the demand for DNA repair. | ||||||