MBD3L4 Inhibitors
MBD3L4 Inhibitors are a class of compounds that influence the functional activity of MBD3L4 by primarily affecting the methylation status of DNA. The inhibitory action of these compounds is rooted in their capacity to either directly inhibit DNA methyltransferase enzymes or to incorporate into DNA and trap these enzymes, leading to reduced levels of DNA methylation. This decreased methylation can impede the ability of MBD3L4 to recognize and bind to methylated DNA, which is central to its role in the cell.
Compounds such as 5-Azacytidine, RG108, and Procainamide work by inhibiting DNA methyltransferase activity, which is expected to reduce the methylation marks that MBD3L4 typically recognizes. This could result in a decreased interaction between MBD3L4 and its DNA targets, effectively inhibiting the protein's normal activity. Other inhibitors, such as Hydralazine and Decitabine, also contribute to demethylation of DNA, further promoting the disassociation of MBD3L4 from methylated DNA regions. Additionally, compounds like SGI-1027 and Disulfiram inhibit the enzyme activity that adds methyl groups to DNA, which in turn would limit the functionality of MBD3L4. Nanaomycin A, while specifically targeting DNMT3B, along with EGCG, a natural compound from green tea, both contribute to a similar outcome by decreasing the methylated substrates available for MBD3L4
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methylation inhibitor that reduces the methylation status of genes. As MBD3L4 is associated with the methyl-CpG-binding domain, demethylation can lead to the altered binding affinity of MBD3L4 to methylated DNA, thus inhibiting its normal function. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor that prevents DNA methylation. By inhibiting this process, RG108 can alter the methylation landscape, potentially decreasing the ability of MBD3L4 to bind to its typical methylated DNA targets. | ||||||
Procainamide hydrochloride | 614-39-1 | sc-202297 | 10 g | $53.00 | ||
A DNA methyltransferase inhibitor, which by reducing DNA methylation levels, could decrease the binding of MBD3L4 to methylated DNA, thereby inhibiting its functionality. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
An antihypertensive drug that also inhibits DNA methylation. Hydralazine may disrupt the interaction between MBD3L4 and methylated DNA by reducing the overall level of DNA methylation. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine analog that incorporates into DNA and traps DNA methyltransferases, reducing DNA methylation. This could impair the ability of MBD3L4 to interact with its methylated DNA targets. | ||||||
SGI-1027 | 1020149-73-8 | sc-473875 | 10 mg | $213.00 | ||
An inhibitor of DNA methyltransferases. By decreasing DNA methylation, SGI-1027 can reduce the binding of MBD3L4 to methylated DNA, inhibiting its function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A hypomethylating agent that can lead to DNA demethylation. Decitabine could inhibit the function of MBD3L4 by decreasing the methylated DNA substrates available for binding. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
An alcohol deterrent that also inhibits DNA methyltransferase enzymes, potentially decreasing the methylation marks that MBD3L4 binds to and inhibiting its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea that has been shown to inhibit DNA methyltransferase activity. EGCG can lead to reduced DNA methylation, potentially inhibiting MBD3L4 binding to methylated DNA. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
A thiodioxopiperazine that inhibits histone methyltransferases. Although it targets histone methylation, chaetocin can indirectly affect DNA methylation patterns, potentially impacting MBD3L4 function. | ||||||