MBD3L4 Activators
MBD3L4 function by modulating the methylation landscape of DNA, which in turn affects the ability of this protein to recognize and bind to methylated regions of the genome. Bromodomain inhibitor JQ1 alters chromatin structure and gene expression by inhibiting the binding of bromodomain-containing proteins to acetylated histones, which can facilitate the activation of MBD3L4 by exposing new methylated DNA sites for binding. Similarly, DNA methyltransferase inhibitors such as 5-aza-2'-deoxycytidine, RG108, SGI-1027, and Zebularine directly reduce DNA methylation levels, which can enhance the functional role of MBD3L4 in binding to DNA. These agents cause hypomethylation of DNA, potentially leading to the activation of MBD3L4 due to increased recognition of aberrantly methylated DNA regions that would otherwise be repressed.
Other chemical activators, including Parthenolide, Disulfiram, Procaine, Hydralazine, Epigallocatechin gallate, and Genistein, operate through similar mechanisms of altering methylation patterns, which can activate MBD3L4. Parthenolide, for instance, can influence DNA methylation and thereby modulate MBD3L4's activity. Disulfiram, known for its DNA methyltransferase inhibitory action, can lead to global hypomethylation, which may alter the binding affinity of MBD3L4 to methylated DNA sites. Procaine and Hydralazine, as demethylating agents, can activate MBD3L4 by enhancing the protein's ability to bind to its target DNA sequences. Epigallocatechin gallate and Genistein, with their DNA methyltransferase inhibitory activity, can change DNA methylation patterns, facilitating the activation of MBD3L4 by altering its DNA-binding dynamics. These chemical-induced modifications in DNA methylation status are critical for the activation of MBD3L4, enabling it to partake in the regulatory processes it is involved with.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a bromodomain inhibitor that blocks the binding of bromodomain-containing proteins to acetylated lysines on histones, which can result in changes to chromatin structure and gene expression. MBD3L4, as a member of the methyl-CpG binding domain family, could be activated due to changes in chromatin state induced by JQ1, leading to the protein's functional activation in recognizing and binding to methylated DNA. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that induces DNA demethylation. By reducing DNA methylation, MBD3L4's ability to bind methylated DNA may be functionally activated due to an increased recognition of aberrantly methylated DNA regions, thus potentially enhancing its role in the regulation of gene expression where it could oppose the repressive effects of methylation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is another DNA methyltransferase inhibitor that prevents DNA methylation. This can lead to aberrant DNA methylation patterns that might activate MBD3L4 by creating new or altered methylation sites for the protein to bind, allowing it to participate in the gene regulatory processes associated with DNA methylation and demethylation. | ||||||
SGI-1027 | 1020149-73-8 | sc-473875 | 10 mg | $209.00 | ||
SGI-1027 is a DNA methyltransferase inhibitor, similar to the previous chemicals. It could activate MBD3L4 by causing hypomethylation of DNA, which may lead to the exposure of sites that MBD3L4 preferentially binds, thus activating its role in gene regulation through the recognition of specific DNA methylation patterns. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a cytidine analog that incorporates into DNA and traps DNA methyltransferases. MBD3L4 activation could occur as a result of the altered methylation landscape caused by zebularine, potentially enhancing the protein's ability to recognize and bind to specific DNA sequences that are less methylated due to the action of this chemical. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is known to have anti-inflammatory and anti-cancer properties and can influence DNA methylation patterns. MBD3L4 might be activated through the altered genomic methylation landscape created by parthenolide, potentially affecting the protein's binding to DNA and its involvement in transcriptional regulation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram is an inhibitor of DNA methyltransferase and could activate MBD3L4 by causing global DNA hypomethylation, which might alter the protein's binding affinity to methylated DNA sites, thereby affecting its regulatory roles in gene expression. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $108.00 $189.00 $399.00 $616.00 | 1 | |
Procaine is a DNA demethylating agent with anesthetic properties. Procaine could activate MBD3L4 by altering the methylation status of DNA and enhancing the protein's ability to bind to its target DNA sequences, thereby activating its functional role in gene expression control. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Hydralazine is an antihypertensive drug that also acts as a DNA demethylating agent. By inducing DNA demethylation, hydralazine could activate MBD3L4 by increasing the availability of hypomethylated DNA for the protein to bind, potentially activating its role in transcription regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea with DNA methyltransferase inhibitory activity. EGCG could activate MBD3L4 by altering DNA methylation patterns, potentially affecting MBD3L4's ability to recognize and bind methylated DNA, and thus activating its role in gene expression. | ||||||