MANBA Activators
MANBA activators comprise a specialized class of compounds known for their ability to modulate the activity of MANBA, an enzyme encoded by the MANBA gene. MANBA, or Mannosidase beta, is a lysosomal enzyme belonging to the glycoside hydrolase family involved in the degradation of complex carbohydrates, specifically in the breakdown of N-linked oligosaccharides. This process plays a crucial role in maintaining cellular homeostasis by ensuring proper turnover of glycoproteins and glycolipids. Activators targeting MANBA likely exert their effects by influencing its catalytic activity, substrate specificity, or subcellular localization. These activators are pivotal in elucidating the biological functions of MANBA and its contributions to cellular metabolism.
Structurally, MANBA activators may exhibit a diverse array of chemical scaffolds, reflecting the complexity required for effective engagement with the target enzyme. These molecules may possess specific binding motifs or functional groups that facilitate their interaction with MANBA, enabling them to modulate its activity with precision. Understanding the structural and biochemical properties of MANBA activators is essential for unraveling the molecular mechanisms underlying the functions of this enzyme and its involvement in cellular processes. Further exploration of the pharmacological characteristics and biological significance of MANBA activators holds promise for advancing our understanding of cellular metabolism and may offer insights into novel strategies for manipulating glycoside degradation pathways in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
May upregulate MANBA by inducing ER stress and subsequent UPR, affecting glycoprotein processing. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Could increase MANBA expression by disrupting ER calcium homeostasis, triggering ER stress and UPR. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Might influence MANBA expression through its role in cellular differentiation and development, potentially affecting lysosomal function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Could elevate MANBA expression by increasing cAMP levels, which may influence lysosomal enzyme regulation. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
May upregulate MANBA by disrupting cholesterol homeostasis, potentially affecting lysosomal membrane composition and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Could enhance MANBA expression by inhibiting mTOR, which can influence lysosomal biogenesis and function. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Might modulate MANBA expression through vitamin D receptor-mediated pathways, potentially influencing lysosomal enzyme regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
May influence MANBA expression through its anti-inflammatory and antioxidant properties, potentially affecting lysosomal function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Could induce MANBA expression as part of its effects on cellular stress pathways and lysosomal function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
As a lysosomotropic agent, might increase MANBA expression by affecting lysosomal pH and function, potentially compensating for impaired degradation capacity. | ||||||