MAN2B2 Activators
MAN2B2 Activators are a collection of chemical compounds that facilitate the enhancement of the functional activity of MAN2B2 by manipulating various biochemical signaling pathways. The compound Forskolin, by increasing cAMP levels, indirectly encourages the functional role of MAN2B2 in glycosylation processes through PKA activation, which can phosphorylate proteins within these pathways. Similarly, PMA activates PKC, and Ionomycin increases intracellular calcium, both of which can lead to the upregulation of glycosylation pathways that MAN2B2 participates in. EGCG, through its inhibitory action on kinases, and Sphingosine-1-phosphate, by stimulating sphingosine kinase, may both enhance MAN2B2's glycosylation functions. The PI3K/AKT pathway, targeted by LY294002, is a crucial regulator of cellular processes, and by inhibiting PI3K, LY294002 may enhance MAN2B2's activity in mannose processing.
Further activation of MAN2B2 can beachieved through the modulation of the MAPK pathway by U0126 and SB203580, both serving as inhibitors to different components of the pathway, thus potentially allowing MAN2B2 to carry out its role more effectively in mannose processing. Genistein's ability to inhibit tyrosine kinase signaling may relieve some of the negative regulation on glycosylation pathways, indirectly supporting the enhancement of MAN2B2's activity. Staurosporine, a broad-acting kinase inhibitor, might also shift the balance of cellular signaling in favor of MAN2B2's role in glycosylation by lifting the inhibition exerted by specific kinases. Wortmannin and A23187, by targeting PI3K and increasing intracellular calcium, respectively, round out the list of activators that could lead to an upregulated functional activity of MAN2B2 by fine-tuning the cellular signaling environment to favor the glycosylation and mannose processing activities that are central to MAN2B2's role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate proteins and alter their activity. This signaling cascade can lead to the enhancement of MAN2B2 activity by promoting the glycosylation processes that MAN2B2 is directly involved in. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which is involved in regulating various cellular processes. Activation of PKC can lead to enhanced MAN2B2 activity by stimulating the glycosylation pathways in which MAN2B2 functions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, potentially enhancing the functional activity of MAN2B2 in its role in glycosylation and mannose processing. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibition properties. It can indirectly enhance the activity of MAN2B2 by modulating kinases involved in glycosylation and mannose processing pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that can activate sphingosine kinase, leading to downstream effects on cellular processes including glycosylation. This may enhance the functional activity of MAN2B2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that alters the PI3K/AKT signaling pathway. By inhibiting this pathway, LY294002 can shift cellular signaling in a way that potentially enhances MAN2B2's role in mannose processing. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK inhibitor that influences the MAPK pathway. By inhibiting MEK, U0126 may enhance MAN2B2 activity by reducing competition from other glycosylation pathways that are negatively regulated by the MAPK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can enhance the activity of MAN2B2 by favoring its role in mannose processing over pathways that are negatively affected by p38 MAPK activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that facilitates the influx of calcium ions, potentially enhancing the activity of MAN2B2 through the activation of calcium-dependent signaling pathways that are crucial for glycosylation processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may indirectly enhance MAN2B2 activity by reducing negative regulatory effects on glycosylation and mannose processing pathways that involve tyrosine kinase signaling. | ||||||