Mammaglobin A Inhibitors
Chemical inhibitors of Mammaglobin A function through various mechanisms that alter the gene expression landscape, leading to a reduction in the protein's functional presence. Trichostatin A, Vorinostat, and Entinostat are all histone deacetylase inhibitors that increase acetylation of histones, which can result in an altered chromatin state. This modification to chromatin structure restricts the transcriptional machinery from accessing the DNA segments that encode for Mammaglobin A, thus functionally inhibiting the protein. Similarly, Romidepsin, a cyclic peptide, and Belinostat, a hydroxamate-type compound, both inhibit histone deacetylases, which can lead to changes in gene expression patterns that include the genes governing the synthesis or regulation of Mammaglobin A. As the acetylation pattern of histones changes, the expression of Mammaglobin A is reduced, diminishing its activity within the cell.
Moreover, Panobinostat, Chidamide, and Valproic Acid, by inhibiting histone deacetylases, bring about widespread changes in the expression of numerous genes, including those that may be directly involved in the production or activity regulation of Mammaglobin A. This results in a decrease in the active levels of Mammaglobin A. Sodium Butyrate also functions in a similar manner, with its inhibition of histone deacetylases possibly leading to a functional inhibition of the Mammaglobin A protein. Mocetinostat, Tacedinaline, and Pracinostat further expand this list of histone deacetylase inhibitors, each contributing to the modification of gene expression profiles. These changes in gene expression are significant enough to include the genes related to Mammaglobin A synthesis and function, thereby reducing the activity of Mammaglobin A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can increase acetylation of histones, leading to alterations in chromatin structure and gene expression. Mammaglobin A, being a protein encoded by genes, may have its expression indirectly inhibited due to the altered chromatin state and subsequent changes in the transcriptional machinery accessing the DNA encoding Mammaglobin A. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, also known as SAHA, is a histone deacetylase inhibitor that, by changing the acetylation status of histones, can inhibit gene expression. As Mammaglobin A expression is dependent on gene transcription, Vorinostat can indirectly inhibit the functional expression of Mammaglobin A through these epigenetic modifications. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a benzamide histone deacetylase inhibitor that can indirectly inhibit the function of Mammaglobin A by altering gene expression profiles, including those genes involved in the synthesis or regulation of Mammaglobin A, thus potentially leading to reduced levels of active protein. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a cyclic peptide histone deacetylase inhibitor. By inhibiting histone deacetylase, it can alter gene expression patterns. This alteration may lead to reduced expression of proteins including Mammaglobin A, thereby functionally inhibiting its presence and activity. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat is a hydroxamate-type histone deacetylase inhibitor. It can indirectly inhibit Mammaglobin A by altering the expression of genes, potentially including those that are involved in the expression or activity regulation of Mammaglobin A, leading to reduced active protein levels. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent pan-histone deacetylase inhibitor that can lead to widespread changes in gene expression. This can indirectly inhibit Mammaglobin A by modifying the expression of genes related to its regulation and synthesis, resulting in decreased protein activity. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Chidamide is a benzamide chemical that acts as a histone deacetylase inhibitor, potentially reducing the expression of various proteins, including Mammaglobin A, by altering gene expression profiles, which could result in functional inhibition of the protein. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is a short-chain fatty acid and histone deacetylase inhibitor that may indirectly inhibit Mammaglobin A by changing the expression of genes involved in its synthesis or regulation, thus reducing the functional levels of the protein. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, can alter the gene expression landscape, potentially including genes that regulate or influence the synthesis of Mammaglobin A, leading to functional inhibition of its protein product. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a benzamide histone deacetylase inhibitor that can change the expression levels of various genes. This may include genes directly involved in the synthesis or activity of Mammaglobin A, which would functionally inhibit the protein. | ||||||