MAGI-3 Inhibitors
MAGI-3 inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of Membrane-Associated Guanylate Kinase, WW and PDZ Domain-Containing Protein 3 (MAGI-3), a scaffolding protein that plays a crucial role in organizing and regulating various signaling pathways at the cell membrane. MAGI-3 is a member of the MAGUK family of proteins, which are characterized by their ability to interact with a variety of signaling molecules through their PDZ, WW, and guanylate kinase-like domains. MAGI-3 is involved in the assembly of multi-protein complexes that are critical for maintaining cell polarity, signal transduction, and the regulation of cell junctions. It interacts with several key proteins, including PTEN, a phosphatase that acts as a tumor suppressor by negatively regulating the PI3K/AKT signaling pathway. By inhibiting MAGI-3, researchers can disrupt these protein-protein interactions, providing a tool to study the specific contributions of MAGI-3 to cellular signaling and structural organization.
In research, MAGI-3 inhibitors are valuable tools for exploring the molecular mechanisms by which MAGI-3 regulates cellular architecture and signaling. By blocking MAGI-3 activity, scientists can investigate how the inhibition affects the assembly and function of signaling complexes at the cell membrane, particularly those involved in maintaining cell polarity and adhesion. This inhibition allows researchers to study the role of MAGI-3 in various signaling pathways, such as the PI3K/AKT pathway, and its influence on cell growth, differentiation, and survival. Additionally, MAGI-3 inhibitors enable the examination of the interactions between MAGI-3 and other proteins involved in the regulation of tight junctions and adherens junctions, providing insights into the complex networks that control cell-cell communication and tissue integrity. Through these studies, the use of MAGI-3 inhibitors enhances our understanding of the critical role of scaffolding proteins in cellular signaling, the regulation of cell junctions, and the broader implications of these processes in maintaining cellular structure and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3K inhibitor, affecting the Akt pathway and thereby possibly influencing MAGI3 activities. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
A highly selective inhibitor of Akt, which could impact MAGI3's interaction with the Akt signaling pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, indirectly affecting Akt signaling and possibly the functional aspects of MAGI3. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
An Akt inhibitor, potentially affecting MAGI3's regulatory role in Akt signaling. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
An alkylphospholipid that inhibits Akt activation, potentially influencing MAGI3's function. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
An Akt inhibitor, potentially modifying the functional aspects of MAGI3 in Akt signaling. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
A PI3K/Akt/mTOR inhibitor, which could indirectly influence MAGI3's activities in these pathways. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $81.00 | 8 | |
An alkylphosphocholine affecting Akt signaling, potentially influencing MAGI3's role. | ||||||