MAGI-3 Antibody (46): sc-136471

MAGI-3 Antibody (46) is a mouse monoclonal IgG2a kappa light chain antibody that detects MAGI-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MAGI-3 (46) antibody is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). MAGI-3, a member of the membrane-associated guanylate kinase (MAGUK) family, plays a crucial role in assembling multiprotein complexes at the membrane-cytoskeletal interface, which is essential for maintaining cellular architecture and signaling pathways. Structurally, MAGI-3 features five PDZ domains and a guanylate kinase domain, which facilitate interactions with other proteins, including tumor suppressor PTEN. This interaction helps regulate cellular signaling pathways that control cell growth and survival, making MAGI-3 significant in various physiological processes and potential disease mechanisms. MAGI-3′s ability to scaffold proteins at the plasma membrane underscores its importance in cellular organization and function, providing insights into its role in health and disease.

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MAGI-3 Antibody (46) References:

1. Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family.  |  Dimitratos, SD., et al. 1999. Bioessays. 21: 912-21. PMID: 10517864
2. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase.  |  Wu, Y., et al. 2000. J Biol Chem. 275: 21477-85. PMID: 10748157
3. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.  |  Wu, X., et al. 2000. Proc Natl Acad Sci U S A. 97: 4233-8. PMID: 10760291
4. MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures.  |  Dobrosotskaya, IY. and James, GL. 2000. Biochem Biophys Res Commun. 270: 903-9. PMID: 10772923
5. Cell signalling: MAGUK magic.  |  Anderson, JM. 1996. Curr Biol. 6: 382-4. PMID: 8723338
6. MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains.  |  Dobrosotskaya, I., et al. 1997. J Biol Chem. 272: 31589-97. PMID: 9395497
7. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.  |  Wood, JD., et al. 1998. Mol Cell Neurosci. 11: 149-60. PMID: 9647693

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAGI-3 Antibody (46) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MAGI-3 Antibody (46) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAGI-3 Antibody (46) Specifications

Alternate Product Name: MAGI-3

Product Clone Name: 46

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 194-298

Epitope Target: MAGI-3

Epitope Species: human

Product Reactivity/Detection: MAGI-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MAGI-3 Antibody (46): AC: Agarose, HRP: Horseradish Peroxidase