MAGE-A8 Inhibitors
MAGE-A8 Inhibitors reference compounds that modulate the activity, stability, or expression of MAGE-A8. While direct inhibition remains less defined, indirect modulation occurs through impacting associated cellular functions or pathways. Trichostatin A and Vorinostat, both histone deacetylase inhibitors, and 5-Azacytidine and Decitabine, DNA methyltransferase inhibitors, can influence the epigenetic state of the cell, potentially altering MAGE-A8 gene expression. These epigenetic changes might activate or repress genes surrounding tumor suppression or progression.
Proteasome inhibitors like Bortezomib can stabilize proteins, potentially impacting MAGE-A8 levels. Compounds such as LY294002, Sorafenib, and Dasatinib target diverse pathways influencing cell survival, growth, or proliferation. The modulation of these pathways can intersect with MAGE-A8's cellular roles. JQ1 and GSK126, affecting bromodomain binding and histone methylation respectively, are another set of epigenetic modulators, which by changing the chromatin state, influence gene expression profiles including that of MAGE-A8. Collectively, these inhibitors provide a toolbox for exploring and indirectly modulating the cellular roles and contexts in which MAGE-A8 operates.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor that can influence the expression of cancer-related genes, like MAGE-A8. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that can demethylate silenced genes and potentially impact MAGE-A8 expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor; could influence protein degradation and subsequently MAGE-A8 levels. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor which can modulate cell survival and growth pathways that MAGE-A8 might be involved in. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2-p53 interaction inhibitor; by stabilizing p53, it might influence cell survival pathways that interact with MAGE-A8. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Kinase inhibitor targeting RAF/MEK/ERK pathway, potentially intersecting with MAGE-A8's role in cell growth. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
EZH2 inhibitor; impacts histone methylation and could influence MAGE-A8 gene expression. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Src family kinase inhibitor; can modulate cellular proliferation pathways that might involve MAGE-A8. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor; affects cellular growth and proliferation which might intersect with MAGE-A8 functions. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor; affects gene expression and may influence MAGE-A8 levels. | ||||||