MacroH2A1 Activators
MACROH2A1, commonly referred to as H2AFY, plays a significant role in the intricacies of chromatin organization. It's activators predominantly function through modulation of various aspects of chromatin dynamics, either directly or indirectly influencing the involvement and function of MACROH2A1. Histone deacetylase inhibitors like Trichostatin A (TSA) and Vorinostat specifically target enzymes responsible for the removal of acetyl groups from histones, leading to an open chromatin configuration which can be associated with the function of MACROH2A1. 5-Azacytidine, which targets DNA methylation, along with other compounds that inhibit different histone methyltransferases, including BIX-01294, Chaetocin, and UNC1999, contribute to the landscape of histone methylation, a determinant of chromatin state. These molecules, along with others targeting different facets of chromatin modification, such as the bromodomain inhibitor PFI-1, exhibit the diversity in the ways chemical compounds can influence the chromatin environment, consequently impacting the role and function of MACROH2A1.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor. By inhibiting HDACs, TSA can promote a more open chromatin structure, thereby potentially enhancing the role of MACROH2A1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound demethylates DNA. DNA methylation affects chromatin structure, and by reducing methylation, this compound can indirectly modulate MACROH2A1's function in chromatin. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A sirtuin inhibitor. Sirtuins are NAD+-dependent deacetylases. By inhibiting sirtuins, nicotinamide can affect chromatin structure and indirectly influence MACROH2A1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor. Like TSA, Vorinostat can affect chromatin structure, indirectly promoting MACROH2A1's role in gene regulation. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Yet another HDAC inhibitor. It promotes acetylation of histones, leading to changes in chromatin structure that can be tied to MACROH2A1 function. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A p300/CBP inhibitor. By targeting histone acetyltransferase p300, C646 modulates chromatin acetylation states, influencing MACROH2A1 indirectly. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Inhibits histone acetyltransferases p300 and PCAF, potentially altering chromatin structure in a way that relates to MACROH2A1's function. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
Inhibitor of the G9a histone methyltransferase. Altering histone methylation states can change chromatin configuration, indirectly relating to MACROH2A1. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Inhibits the SUV39H1 histone methyltransferase. This affects chromatin methylation patterns, which can indirectly modulate MACROH2A1. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
A bromodomain inhibitor. By targeting bromodomains, PFI-1 influences reading of acetylated histones, which can affect chromatin dynamics and thus MACROH2A1 indirectly. | ||||||