mAChR M4 Inhibitors
SEE ALSO...
Items 1 to 10 of 15 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tropicamide | 1508-75-4 | sc-202371 | 100 mg | $31.00 | 3 | |
Tropicamide acts as a selective antagonist at muscarinic M4 receptors, exhibiting unique binding dynamics that disrupt typical receptor activation. Its molecular interactions involve competitive inhibition, leading to altered signaling pathways. The compound's affinity for the M4 subtype is notable, as it influences downstream effects on neurotransmitter release. Tropicamide's rapid kinetics facilitate transient modulation of receptor activity, making it a key player in the regulation of cholinergic signaling. | ||||||
AF-DX 384 | 118290-27-0 | sc-203498 sc-203498A | 10 mg 50 mg | $129.00 $548.00 | ||
AF-DX 384 is a selective antagonist for muscarinic M4 receptors, characterized by its unique allosteric modulation of receptor conformation. This compound engages in specific hydrogen bonding and hydrophobic interactions, which stabilize the inactive state of the receptor. Its kinetic profile reveals a fast association and dissociation rate, allowing for precise temporal control over cholinergic signaling pathways. The distinct selectivity for M4 enhances its role in fine-tuning neural communication. | ||||||
Biperiden hydrochloride | 1235-82-1 | sc-203846 sc-203846A | 10 mg 50 mg | $112.00 $422.00 | ||
Biperiden hydrochloride acts as a modulator of muscarinic M4 receptors, exhibiting a unique binding affinity that influences receptor dynamics. Its molecular structure facilitates specific electrostatic interactions, promoting a conformational shift that alters receptor activity. The compound's reaction kinetics demonstrate a notable balance between rapid binding and prolonged receptor occupancy, enabling nuanced regulation of cholinergic pathways. This selectivity underscores its potential in influencing synaptic transmission. | ||||||
Methoctramine | 104807-46-7 | sc-257709B sc-257709 sc-257709A | 5 mg 10 mg 25 mg | $163.00 $306.00 $444.00 | 1 | |
Methoctramine acts as a selective antagonist for mAChR M4. It impedes the receptor′s function by binding to its allosteric site, inducing a conformational change that hinders its interaction with acetylcholine. Consequently, this inhibition disrupts the intracellular signaling cascades associated with mAChR M4, particularly those involved in neurotransmission and cellular responses. | ||||||
AF-DX 116 | 102394-31-0 | sc-223772 | 5 mg | $107.00 | 3 | |
AF-DX 116 selectively targets muscarinic M4 receptors, showcasing a distinct interaction profile characterized by its ability to stabilize receptor conformations. The compound engages in specific hydrogen bonding and hydrophobic interactions, enhancing its binding affinity. Its kinetic behavior reveals a rapid association rate coupled with a slow dissociation, allowing for sustained receptor modulation. This unique dynamic contributes to its role in fine-tuning cholinergic signaling pathways. | ||||||
PD 102807 | 23062-91-1 | sc-203659 sc-203659A | 1 mg 10 mg | $202.00 $950.00 | 2 | |
PD 102807 exhibits a selective affinity for muscarinic M4 receptors, demonstrating unique allosteric modulation capabilities. Its binding induces conformational changes that enhance receptor activity through specific electrostatic interactions. The compound's reaction kinetics are marked by a moderate association rate and prolonged retention at the receptor site, facilitating nuanced regulation of neurotransmitter release. This behavior underscores its potential in influencing cholinergic neurotransmission dynamics. | ||||||
Scopolamine | 51-34-3 | sc-473216 sc-473216A sc-473216B | 100 mg 500 mg 1 g | $169.00 $496.00 $771.00 | 2 | |
Scopolamine, an alkaloid found in plants, acts as a potent mAChR M4 inhibitor by competitively binding to the receptor's orthosteric site. This binding prevents acetylcholine from effectively engaging with the receptor, leading to the inhibition of downstream signaling pathways. | ||||||
(S)-(+)-Dimethindene maleate | 121367-05-3 | sc-361329 sc-361329A | 10 mg 50 mg | $235.00 $960.00 | 1 | |
(S)-(+)-Dimethindene maleate selectively engages with muscarinic M4 receptors, showcasing distinct binding characteristics that promote receptor stabilization. Its molecular interactions involve hydrophobic contacts and hydrogen bonding, which fine-tune receptor conformation. The compound exhibits a unique kinetic profile, characterized by a slow dissociation rate, allowing for sustained receptor activation. This prolonged engagement may influence downstream signaling pathways, highlighting its intricate role in modulating cholinergic activity. | ||||||
4-DAMP | 1952-15-4 | sc-200167 | 50 mg | $192.00 | 5 | |
4-DAMP is a selective antagonist of muscarinic M4 receptors, exhibiting unique binding dynamics that enhance receptor specificity. Its molecular structure facilitates strong hydrophobic interactions and strategic electrostatic contacts, which contribute to its affinity. The compound's kinetic behavior is marked by a rapid association rate, leading to effective receptor occupancy. This interaction profile may alter receptor desensitization processes, impacting cholinergic signaling pathways in a nuanced manner. | ||||||
Himbacine | 6879-74-9 | sc-200181 sc-200181A | 1 mg 5 mg | $77.00 $315.00 | 3 | |
Himbacine acts as a selective modulator of muscarinic M4 receptors, characterized by its unique allosteric binding site interactions. The compound exhibits a distinctive conformational flexibility that allows it to stabilize receptor states, influencing downstream signaling cascades. Its kinetic profile reveals a slow dissociation rate, promoting prolonged receptor engagement. This behavior may lead to altered receptor dynamics, potentially affecting the overall cholinergic network in intricate ways. | ||||||