MA1 Inhibitors
MA1 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of MA1 enzymes. These enzymes, also known as monoamine oxidase A, are primarily found in the outer membrane of mitochondria and play a crucial role in the metabolism of neurotransmitters such as serotonin, norepinephrine, and dopamine. By inhibiting MA1, these compounds can modulate the levels of these neurotransmitters in the brain, potentially leading to various physiological and behavioral effects. MA1 inhibitors are typically small molecules that can penetrate the blood-brain barrier, allowing them to exert their effects directly within the central nervous system.
Structurally, MA1 inhibitors can vary widely, but they often contain specific functional groups that interact with the active site of the enzyme, thereby blocking its activity. Some MA1 inhibitors are reversible, meaning that they bind to the enzyme temporarily and can be displaced, while others are irreversible and form a permanent bond with the enzyme. The selectivity of MA1 inhibitors can also vary, with some compounds exhibiting greater affinity for MA1 over the closely related enzyme MAO-B. This selectivity can be important in minimizing off-target effects and unwanted interactions with other enzymes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine is a DNA methyltransferase inhibitor. It could reduce PNMA1 expression by modifying DNA methylation patterns around the PNMA1 gene, thereby influencing its transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to azacitidine, decitabine acts as a DNA methyltransferase inhibitor. It might affect the methylation status of the PNMA1 gene, potentially reducing its expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil interferes with RNA processing, which could hypothetically impact the maturation of PNMA1 mRNA transcripts, reducing protein synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and interferes with the transcription process. This action could impede the transcription of the PNMA1 gene. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol inhibits xanthine oxidase, potentially affecting purine metabolism. This might indirectly impact the synthesis of nucleotides required for PNMA1 gene transcription. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis. This could lead to a reduction in PNMA1 gene replication and, subsequently, its expression. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C forms cross-links in DNA, inhibiting DNA synthesis. This could reduce the replication and transcription of the PNMA1 gene. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin targets DNA topoisomerase I, preventing DNA unwinding. This could hinder the transcription of the PNMA1 gene. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA, affecting the transcription process. This could impede the transcription of the PNMA1 gene. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $103.00 $429.00 $821.00 $1538.00 | 4 | |
Similar to doxorubicin, daunorubicin intercalates into DNA, which might affect the transcription of the PNMA1 gene. | ||||||