LYRM4 Inhibitors
Chemical inhibitors of LYRM4 disrupt its role in mitochondrial complex I assembly and function through various mechanisms. Rotenone and Piericidin A are direct inhibitors of mitochondrial complex I where LYRM4 is integrally involved. By inhibiting complex I, these chemicals prevent the proper incorporation of LYRM4 into the complex, thereby compromising its function. Tenovin-6, by disrupting SIRT1 activity, affects mitochondrial biogenesis and function, leading to a decrease in LYRM4's functional integration within the mitochondria. Carboxin, though a specific inhibitor of complex II, and TTFA, which targets complex II as well, can indirectly affect LYRM4 by causing broader disruptions in mitochondrial function that can ripple through to complex I where LYRM4 operates.
Further down the electron transport chain, Atovaquone and Antimycin A inhibit mitochondrial electron transport at the level of the cytochrome bc1 complex (complex III). This action can lead to reduced electron flow which, in turn, impacts the function of LYRM4 in complex I assembly. Similarly, inhibitors of complex IV, such as Sodium azide and KCN, by halting cytochrome c oxidase, can indirectly inhibit LYRM4 due to the interconnectedness of the mitochondrial respiratory chain. Oligomycin A, targeting ATP synthase (complex V), leads to a reduction in ATP synthesis, which can compromise mitochondrial function including the activity of LYRM4. Additionally, Auranofin, by inhibiting thioredoxin reductase, affects the redox state in cells, which can impair mitochondrial function and thus inhibit the integration or function of LYRM4 in complex I assembly. These chemical inhibitors, through various points of action within the mitochondrial respiratory chain, demonstrate the critical role LYRM4 plays in mitochondrial function and the delicate balance required for its proper operation within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. LYRM4 is involved in the assembly of mitochondrial complex I. By inhibiting complex I, Rotenone can disrupt the function of LYRM4 by preventing its proper incorporation into the complex. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A, like Rotenone, inhibits mitochondrial complex I. It can inhibit LYRM4 by blocking the formation of the complex I, where LYRM4 plays a crucial role in the assembly and stabilization of the complex. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 disrupts SIRT1 activity. Since SIRT1 is involved in mitochondrial biogenesis and function, and LYRM4 is a mitochondrial protein, the inhibition of SIRT1 by Tenovin-6 can lead to a reduction in LYRM4 functional integration. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin specifically inhibits succinate dehydrogenase (complex II) in mitochondria. Although LYRM4 is part of complex I, the inhibition of complex II can result in broader disruptions of mitochondrial function, indirectly inhibiting LYRM4. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) is an inhibitor of mitochondrial complex II. By disrupting the mitochondrial respiratory chain downstream of where LYRM4 operates, TTFA can cause a functional inhibition of LYRM4 as part of a complex I. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone is a selective inhibitor of mitochondrial electron transport at the level of cytochrome bc1 complex (complex III). Its action can lead to a reduced electron flow impacting LYRM4 function in complex I assembly indirectly. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits the cytochrome bc1 complex (complex III). By inhibiting complex III, it can create a backlog of electrons, which can disturb the proper assembly or function of LYRM4 in complex I. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase (complex IV). Inhibition of this complex can affect mitochondrial function and thus indirectly inhibit the proper integration or function of LYRM4 in complex I assembly. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A inhibits ATP synthase (complex V). As ATP synthesis is reduced, overall mitochondrial function can be compromised, including the activity of LYRM4 in complex I. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin inhibits thioredoxin reductase, which is essential for maintaining a proper redox state in cells. A disrupted redox state can impair mitochondrial function and thus can inhibit the integration or function of LYRM4 in complex I. | ||||||