Ly-6C2 Inhibitors
Chemical inhibitors of Ly-6C2 encompass a range of compounds that target various signaling pathways and cellular processes, which can influence the activity and presence of this protein on the cell surface. Cyclopamine acts by binding to the Smoothened receptor, which is part of the Hedgehog signaling pathway, leading to a decrease in the pathway's activity and potentially affecting Ly-6C2. LY294002 is a potent inhibitor of phosphoinositide 3-kinases, which can lead to the reduced activity of downstream pathways like Akt, having an impact on the stabilization and surface expression of Ly-6C2. Similarly, A-674563 inhibits Akt1, which is part of the same signaling cascade, and can have an effect on Ly-6C2 activity.
PD98059 and U0126 are chemical inhibitors that target the MAPK/ERK pathway by inhibiting MEK. This inhibition can prevent the activation of this pathway, which is involved in various cellular processes that can influence the expression and functionality of Ly-6C2. SB203580, on the other hand, specifically inhibits p38 MAP kinase, which can regulate inflammatory responses and may indirectly affect Ly-6C2 function. SP600125 targets the JNK pathway, which can decrease the activity of transcription factors that are responsible for the regulation of Ly-6C2 at the protein level. WZ4003 inhibits NUAK family kinase 1, which can affect the stability and localization of Ly-6C2. BMS-345541 selectively inhibits the IκB kinase complex, impacting NF-κB signaling, which can be involved in the regulation of immune cell activity and the function of Ly-6C2. D4476, acting as a casein kinase 1 inhibitor, can impact Wnt signaling, which may affect Ly-6C2 processes. MLN4924, an inhibitor of the NEDD8-activating enzyme, can disrupt the neddylation pathway essential for protein function and stability, including that of Ly-6C2. Lastly, XAV939, by inhibiting tankyrase, can lead to the stabilization of β-catenin in the Wnt signaling pathway, which can indirectly affect Ly-6C2 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Inhibits the Hedgehog signaling pathway by binding to the Smoothened receptor, which could reduce the activity of Ly-6C2 as Hedgehog signaling has been implicated in the regulation of a subset of Ly-6 family proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), which could lead to the reduction of downstream signaling pathways such as Akt that may be involved in the stabilization and activity of Ly-6C2 on the cell surface. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which in turn prevents the activation of MAPK/ERK pathway that could be linked to the cellular processes governing the expression and functionality of Ly-6C2 at the cell surface. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective inhibitor of both MEK1 and MEK2, which could impede the MAPK/ERK pathway that may influence the activity of Ly-6C2, likely affecting its cellular trafficking or surface expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Specifically inhibits p38 MAP kinase, a pathway that can regulate inflammatory responses and could have an indirect effect on the function of Ly-6C2, particularly if it is involved in cell-signaling during immune responses. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which could lead to a decrease in the activity of transcription factors that regulate the expression and potentially the function of Ly-6C2 at the protein level. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
Inhibits NUAK family kinase 1 (NUAK1), which could affect the stability and localization of Ly-6C2, as kinase signaling has been shown to regulate the trafficking and function of various cell surface proteins. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $306.00 | 1 | |
Selectively inhibits the IκB kinase (IKK) complex, which may impact NF-κB signaling that could be involved in the regulation of immune cell activity and possibly the function of Ly-6C2 as part of the immune response. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
Inhibits the NEDD8-activating enzyme, which could disrupt the neddylation pathway that is essential for the regulation of protein function and stability, potentially leading to a decrease in the functional activity of Ly-6C2. | ||||||
A-674563 | 552325-73-2 | sc-364393 sc-364393A | 2 mg 5 mg | $232.00 $413.00 | ||
A potent inhibitor of Akt1, which could impact the PI3K/Akt signaling pathway and therefore might inhibit the downstream processes that regulate the activity and stability of Ly-6C2. | ||||||