Ly-6A/E Inhibitors
Ly-6A/E inhibitors represent a diverse set of compounds that interact with various signaling pathways potentially connected to the function of Ly-6A/E, a glycosylphosphatidylinositol-anchored protein involved in multiple cellular functions, including cell adhesion, migration, and immune response regulation. These inhibitors are not specific to Ly-6A/E but are selected based on their ability to influence signaling pathways that may be associated with the biological processes in which Ly-6A/E is implicated.
The chemical inhibitors encompass a range of small molecules designed to interfere with key signaling kinases such as JAK, PI3K, MEK, STAT3, and mTOR, all of which are pivotal regulators of cell proliferation, survival, and differentiation. By modulating these kinases, the compounds can alter the downstream effects that Ly-6A/E may have on these cellular processes. Similarly, antagonists and inhibitors that target G-protein-coupled receptors (CXCR4), Src family kinases, and signaling pathways like Wnt, Hedgehog, Notch, and TGF-β provide a broad approach to potentially modulating the cellular context in which Ly-6A/E operates. These inhibitors are integral tools in research focused on dissecting the complex cellular networks and may shed light on the indirect modulation of Ly-6A/E's role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $153.00 $332.00 | 59 | |
This compound inhibits the Janus kinase (JAK) signaling pathway, which can be involved in the downstream effects of Ly-6A/E signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This inhibits phosphoinositide 3-kinases (PI3Ks), which may be part of the signaling cascade of Ly-6A/E. | ||||||
Netupitant | 290297-26-6 | sc-478156 | 5 mg | $419.00 | ||
This molecule interferes with the NF-κB pathway, which could be linked to Ly-6A/E's role in immune response regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
This compound inhibits MEK1/2, which are part of the MAPK/ERK pathway, potentially connected to Ly-6A/E signaling. | ||||||
Stat3 Inhibitor VI, S3I-201 | 501919-59-1 | sc-204304 | 10 mg | $148.00 | 104 | |
This inhibitor targets Signal Transducer and Activator of Transcription 3 (STAT3), possibly a downstream target of Ly-6A/E involved signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This compound inhibits mTOR, which may intersect with Ly-6A/E related pathways in cell growth and proliferation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
This inhibits Src family kinases, which could be part of the signaling network associated with Ly-6A/E. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
This compound inhibits Wnt production, potentially affecting processes where Ly-6A/E is involved. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
This molecule inhibits the Hedgehog signaling pathway, which might interact with Ly-6A/E's function. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
This γ-secretase inhibitor disrupts Notch signaling, which could be relevant to Ly-6A/E's role in cell differentiation. | ||||||