LXR alpha Activators
Items 1 to 10 of 16 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $137.00 $474.00 $3060.00 | ||
GW 3965 hydrochloride acts as a potent liver X receptor (LXR) alpha agonist, characterized by its ability to engage in specific hydrogen bonding interactions with the receptor's ligand-binding domain. This compound promotes the recruitment of coactivators, enhancing transcriptional activity. Its unique structural features enable selective modulation of lipid homeostasis, influencing the expression of genes involved in cholesterol and fatty acid metabolism through distinct signaling cascades. | ||||||
22(R)-hydroxycholesterol | 17954-98-2 | sc-205106 sc-205106A sc-205106B | 1 mg 5 mg 10 mg | $108.00 $350.00 $600.00 | 1 | |
An oxysterol that can act as a natural ligand for LXRα, leading to its activation. | ||||||
LXRα/β Agonist | 264206-85-1 | sc-221864 | 10 mg | $327.00 | ||
LXRα/β Agonist is a selective modulator of liver X receptors, exhibiting unique binding affinity that stabilizes the receptor's active conformation. This compound facilitates the recruitment of transcriptional coactivators, leading to enhanced gene expression. Its distinct molecular interactions promote the regulation of metabolic pathways, particularly those governing lipid metabolism and cholesterol homeostasis, through intricate signaling networks that influence cellular responses. | ||||||
GW3965 | 405911-09-3 | sc-490151 sc-490151A sc-490151B | 10 mg 50 mg 1 g | $260.00 $872.00 $1637.00 | ||
A synthetic LXR agonist that activates LXRα and has been shown to regulate lipid metabolism and inflammation. | ||||||
27-Hydroxycholesterol | 20380-11-4 | sc-358756 sc-358756A sc-358756B | 5 mg 10 mg 60 mg | $289.00 $545.00 $3069.00 | 35 | |
27-Hydroxycholesterol acts as a potent ligand for liver X receptor alpha (LXRα), engaging in specific hydrophobic and hydrogen bonding interactions that enhance receptor activation. This compound influences the transcriptional landscape by modulating the expression of genes involved in cholesterol and fatty acid metabolism. Its unique ability to cross the blood-brain barrier allows it to impact central nervous system functions, highlighting its role in lipid signaling pathways. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $87.00 $220.00 | 5 | |
Synthetic agonist that potently activates both LXRα and LXRβ. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
While primarily a ligand for RXRs, it may have indirect effects on LXRα activation when partnered with RXR in heterodimers. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $159.00 $465.00 | 14 | |
Isoprenoid alcohol that has been shown to upregulate LXRα expression in certain studies. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $27.00 $115.00 | ||
A primary bile acid that can influence LXRα expression, though it's primarily an FXR agonist. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
A PPARγ agonist that might indirectly modulate LXRα expression via cross-talk between PPARγ and LXRα signaling. | ||||||