LTRPC7 Activators
LTRPC7 activators, which affect the TRPM7 channel, operate through various indirect mechanisms due to the multifunctional nature of the protein. These compounds often modulate TRPM7 activity by altering the concentration of substrates and ions that regulate channel function or by influencing signaling pathways that can phosphorylate the channel or its associated regulatory proteins. For instance, agents that alter cellular magnesium levels, such as magnesium sulfate, can directly modulate TRPM7 activity by providing magnesium, which is a cofactor for the channel's conductance.
Other compounds listed, such as 2-APB and cinnamaldehyde, interact with TRP channels more broadly and may affect TRPM7 by altering the lipid environment of the membrane or through secondary signaling cascades. Additionally, ionophores like ionomycin increase intracellular calcium levels, potentially affecting TRPM7 through calmodulin-dependent or independent pathways. Compounds that activate protein kinase C, such as PMA, can phosphorylate TRPM7 or its regulatory proteins, modulating its activity. Moreover, agents that have a complex interaction with cellular membranes, like spermine, can influence membrane-bound TRPM7 indirectly.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
As an extracellular source of magnesium, it can directly increase the activity of TRPM7 channels by providing its primary substrate. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
While primarily a blocker of L-type calcium channels, nifedipine at certain concentrations can paradoxically upregulate TRPM7 activity, possibly through indirect effects on cellular ion homeostasis. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $33.00 $83.00 | 5 | |
Similar to nifedipine, nicardipine can modulate ion channel activity and may exert an indirect activating effect on TRPM7 under specific experimental conditions. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde has been shown to activate TRP channels, and while its action on TRPM7 is not direct, it can influence TRPM7 activity through modulation of related signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which can phosphorylate TRPM7 or its regulatory proteins, thereby modulating its activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, which can indirectly activate TRPM7 through secondary signaling mechanisms. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Although often used as an inhibitor, ruthenium red can have complex effects on ion channels, potentially activating TRPM7 in a context-dependent manner. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $90.00 | ||
Lanthanum ions can affect TRPM7 activity; while typically inhibitory, they can also activate the channel under certain experimental conditions. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
As a polyamine, spermine can influence the charge and stability of cellular membranes, which can indirectly modulate TRPM7 channel activity. | ||||||