LTRPC7 Antibody (H-4): sc-271099
- LTRPC7 Antibody (H-4) is a mouse monoclonal IgG1 κ LTRPC7 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1251-1550 mapping within a C-terminal cytoplasmic domain of LTRPC7 of human origin
- LTRPC7 Antibody (H-4) is recommended for detection of LTRPC7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-LTRPC7 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for LTRPC7 Antibody (H-4) for WB and IHC(P) applications. This reagent is now offered in a bundle with LTRPC7 Antibody (H-4) (see ordering information below).
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SEE ALSO...
LTRPC7 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects LTRPC7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). LTRPC7 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LTRPC7 protein plays a crucial role in calcium signaling, functioning as a divalent cation channel that facilitates calcium and magnesium ion entry into cells. LTRPC7 function is particularly important for various physiological processes, including muscle contraction, neurotransmitter release, and cellular signaling pathways. LTRPC7-mediated store-operated calcium entry is vital for replenishing intracellular calcium stores depleted during cellular activation, thus maintaining cellular homeostasis and function. LTRPC7 belongs to the long TRPC subfamily, characterized by a large open reading frame of approximately 1600 amino acids, which contributes to unique regulatory properties and interactions with other proteins involved in calcium signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LTRPC7 Antibody (H-4) References:
- From worm to man: three subfamilies of TRP channels. | Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
- Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. | Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
- LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. | Nadler, MJ., et al. 2001. Nature. 411: 590-5. PMID: 11385574
- ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. | Perraud, AL., et al. 2001. Nature. 411: 595-9. PMID: 11385575
- Immunocyte Ca2+ influx system mediated by LTRPC2. | Sano, Y., et al. 2001. Science. 293: 1327-30. PMID: 11509734
- TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration. | Qiao, W., et al. 2021. Nat Commun. 12: 2885. PMID: 34001887
- TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation. | Chen, Y., et al. 2022. J Exp Clin Cancer Res. 41: 44. PMID: 35101076
- TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis. | Zhou, R., et al. 2022. Redox Biol. 55: 102411. PMID: 35917680
- The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis. | Wu, W., et al. 2023. Cell Death Dis. 14: 183. PMID: 36878949
- Structural mechanisms of TRPM7 activation and inhibition. | Nadezhdin, KD., et al. 2023. Nat Commun. 14: 2639. PMID: 37156763
- A novel capacitative calcium entry channel expressed in excitable cells. | Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496
- Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain. | Nagamine, K., et al. 1998. Genomics. 54: 124-31. PMID: 9806837
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTRPC7 Antibody (H-4) | sc-271099 | 200 µg/ml | $322.00 | |||
LTRPC7 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-525782 | 200 µg Ab; 10 µg BP | $361.00 | |||
LTRPC7 Antibody (H-4) AC | sc-271099 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LTRPC7 Antibody (H-4) HRP | sc-271099 HRP | 200 µg/ml | $322.00 | |||
LTRPC7 Antibody (H-4) FITC | sc-271099 FITC | 200 µg/ml | $336.00 | |||
LTRPC7 Antibody (H-4) PE | sc-271099 PE | 200 µg/ml | $349.00 | |||
LTRPC7 Antibody (H-4) Alexa Fluor® 488 | sc-271099 AF488 | 200 µg/ml | $364.00 | |||
LTRPC7 Antibody (H-4) Alexa Fluor® 546 | sc-271099 AF546 | 200 µg/ml | $364.00 | |||
LTRPC7 Antibody (H-4) Alexa Fluor® 594 | sc-271099 AF594 | 200 µg/ml | $364.00 | |||
LTRPC7 Antibody (H-4) Alexa Fluor® 647 | sc-271099 AF647 | 200 µg/ml | $364.00 | |||
LTRPC7 Antibody (H-4) Alexa Fluor® 680 | sc-271099 AF680 | 200 µg/ml | $364.00 | |||
LTRPC7 Antibody (H-4) Alexa Fluor® 790 | sc-271099 AF790 | 200 µg/ml | $364.00 |