LTB4DH Activators
The chemical class referred to as LTB4DH Activators includes compounds that, while not necessarily binding directly to leukotriene B4 dehydrogenase (LTB4DH), possess the ability to indirectly modulate its activity or expression. LTB4DH is an enzyme involved in the metabolism of leukotriene B4 (LTB4), a potent pro-inflammatory mediator. One group of LTB4DH activators comprises non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen. Ibuprofen indirectly impacts LTB4DH activity by mitigating inflammation. As inflammation often triggers the production of pro-inflammatory mediators, including LTB4, the reduction in inflammatory responses achieved by Ibuprofen can indirectly lead to decreased LTB4DH activation. Similarly, Zileuton, an inhibitor of 5-lipoxygenase, a precursor enzyme in the leukotriene biosynthesis pathway, indirectly influences LTB4DH. By inhibiting 5-lipoxygenase, Zileuton reduces the availability of LTB4DH's substrate, LTA4, and subsequently impacts the downstream product, LTB4. This indirectly limits LTB4DH's role in LTB4 metabolism. Another category of LTB4DH activators includes natural compounds like Curcumin. Curcumin is known for its anti-inflammatory properties and can indirectly affect LTB4DH by reducing inflammation and curbing the production of pro-inflammatory mediators, including LTB4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is an inhibitor of 5-lipoxygenase, an enzyme upstream of LTB4DH in the leukotriene biosynthesis pathway. By inhibiting 5-lipoxygenase, zileuton can indirectly reduce LTB4DH's substrate, LTA4, and its downstream product, LTB4. | ||||||
Montelukast Sodium | 151767-02-1 | sc-202231 sc-202231A sc-202231B | 10 mg 25 mg 250 mg | $50.00 $83.00 $158.00 | 5 | |
Montelukast is a leukotriene receptor antagonist that can indirectly influence LTB4DH activity by blocking the action of leukotrienes, including LTB4, on their receptors, thereby reducing their overall impact. | ||||||
Resolvin D1 | 872993-05-0 | sc-204877 sc-204877A | 10 µg 25 µg | $257.00 $602.00 | 1 | |
Resolvin D1 is an anti-inflammatory lipid mediator that can indirectly affect LTB4DH by promoting the resolution of inflammation and reducing the levels of pro-inflammatory mediators like LTB4. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and can indirectly influence LTB4DH by reducing inflammation and the production of pro-inflammatory mediators, including leukotrienes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with anti-inflammatory properties that can indirectly impact LTB4DH by reducing inflammation and the release of inflammatory mediators. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural polyphenol that can indirectly affect LTB4DH by modulating inflammatory pathways and reducing the production of pro-inflammatory mediators. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC is an antioxidant that can indirectly influence LTB4DH by reducing oxidative stress, which is often associated with inflammation and the production of inflammatory mediators. | ||||||
Gingerol | 23513-14-6 | sc-201519 sc-201519A | 5 mg 20 mg | $107.00 $379.00 | 5 | |
Gingerol, a compound found in ginger, can indirectly impact LTB4DH by reducing inflammation and the production of pro-inflammatory mediators. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea that can indirectly affect LTB4DH by modulating inflammatory pathways and reducing the production of pro-inflammatory mediators. | ||||||