Molecular structure of Resolvin D1, CAS Number: 872993-05-0
Resolvin D1 (CAS 872993-05-0)
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Alternate Names:
RvD1
Application:
Resolvin D1 is an anti-inflammatory that reduces human polymorphonuclear leukocyte transendothelial migration
CAS Number:
872993-05-0
Purity:
≥95%
Molecular Weight:
376.5
Molecular Formula:
C22H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state. It is part of a larger family of compounds known as specialized pro-resolving lipid mediators (SPMs). It is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. This lipid mediator exerts its effects by binding to specific G protein-coupled receptors (GPCRs) on the surfaces of various cell types involved in the inflammatory response, including leukocytes and endothelial cells.
Resolvin D1 (CAS 872993-05-0) References
- Resolvin D1 and its GPCRs in resolution circuits of inflammation. | Recchiuti, A. 2013. Prostaglandins Other Lipid Mediat. 107: 64-76. PMID: 23500003
- Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease. | Krashia, P., et al. 2019. Nat Commun. 10: 3945. PMID: 31477726
- Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization. | Shan, K., et al. 2020. J Cell Mol Med. 24: 8045-8056. PMID: 32469149
- Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation. | Hosseini, Z., et al. 2021. Arterioscler Thromb Vasc Biol. 41: 1062-1075. PMID: 33472399
- Possible protective effect of resolvin D1 on inflammation in atrial fibrillation: involvement of ER stress mediated the NLRP3 inflammasome pathway. | Yarmohammadi, F., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 1613-1619. PMID: 34216224
- Resolvin D1, therapeutic target in acute respiratory distress syndrome. | Molaei, E., et al. 2021. Eur J Pharmacol. 911: 174527. PMID: 34582846
- Resolvin D1 attenuates CCl4 Induced Liver Fibrosis by Inhibiting Autophagy-Mediated HSC activation via AKT/mTOR Pathway. | Li, J., et al. 2021. Front Pharmacol. 12: 792414. PMID: 34987404
- Resolvin D1 inhibits the proliferation of osteoarthritis fibroblast-like synoviocytes through the Hippo-YAP signaling pathway. | Su, S., et al. 2022. BMC Musculoskelet Disord. 23: 149. PMID: 35168589
- Resolvin D1 Inhibits Corneal Inflammation in Staphylococcus Aureus Keratitis. | Kim, SY. and Lee, JE. 2022. Ocul Immunol Inflamm. 1-8. PMID: 35522258
- Resolvin D1: A key endogenous inhibitor of neuroinflammation. | Roohbakhsh, A., et al. 2022. Biofactors. 48: 1005-1026. PMID: 36176016
- Resolvin D1 shows osseous-protection via RANK reduction on monocytes during orthodontic tooth movement. | Klein, Y., et al. 2022. Front Immunol. 13: 928132. PMID: 36275768
- Resolvin D1 modulates periodontal ligament fibroblast function. | Zarrough, AE., et al. 2022. J Periodontol.. PMID: 36416879
- Resolvin D1 attenuates sepsis induced acute kidney injury targeting mitochondria and NF-κB signaling pathway. | Wang, L., et al. 2022. Heliyon. 8: e12269. PMID: 36578378
Inhibitor of:
TREM-1.Activator of:
BPI, CD300LF, CKR-10, COL4A1, CRS1C-2, Fpr-rs4, FPR2, GPR87, group IVB sPLA2, group VI iPLA2, Integrin αL, LPLUNC1, LTB4DH, MrgA4, MrgB2, and MRGX1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Resolvin D1, 10 µg | sc-204877 | 10 µg | $257.00 | |||
Resolvin D1, 25 µg | sc-204877A | 25 µg | $602.00 |