Resolvin D1 (CAS 872993-05-0)
Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)(1), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. It reduces human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. It exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.
Download SDS (MSDS)
SAMPLE Certificate of Analysis (COA)
Resolvin D1 | CAS 872993-05-0 SAMPLE Certificate of AnalysisCertificate of Analysis
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Identification (Mass Spectrometry - ESI) | M-H+: 375.3 | M-H+: 375.9 |
| Purity (HPLC) | ≥ 95% | 99.2%Retention time actual: 21.10 min |
| UV/Visible Spectrum | Solvent: ethanolλmax: 302 nmAbs: 0.6640Conc.: 100.00 mg/ml | λmax: 302 nmAbs: 0.6880Conc.: 103612.80 µg/ml |
| λmax | 302 nm | 302 nm |
TEST CONDITIONS
HPLC Conditions: Column: C18, 5µ, 4.6 X 250 mm; Mob Phase: Methanol: Water: Acetic acid (60: 40: 0.1); Flow Rate: 1.00 ml/min; Detector UV: 302 nm
Resolvin D1 (CAS 872993-05-0) Product Citations
See how others have used Resolvin D1 (CAS 872993-05-0). Click on the entry to view the PubMed entry .
PMID: 34570918 | Resolvin D1 prevents cadmium chloride-induced memory loss and hippocampal damage in rats by activation/upregulation of PTEN-induced suppression of PI3K/Akt/mTOR signaling pathway. | Shati, AA. et al. 2022. Clin Exp Pharmacol Physiol. 49: 275-290.