LSm7 Activators
LSm7 activators encompass a range of chemicals that indirectly modulate the expression or function of the LSm7 protein, which is associated with RNA splicing activities. The action of these chemicals primarily influences the transcriptional and post-transcriptional regulation of gene expression, chromatin remodeling, and protein stability. For instance, inhibitors of histone deacetylases like Trichostatin A and SAHA can enhance the transcription of splicing factor genes by inducing a more open chromatin conformation, facilitating access to transcriptional machinery. This indirectly could lead to an increase in LSm7 protein as part of the broader upregulation of splicing components.
Further, compounds like Leptomycin B and MG132 have roles in the nuclear-cytoplasmic trafficking and degradation of proteins, respectively. Leptomycin B's inhibition of CRM1-mediated nuclear export can result in the retention and consequent accumulation of nuclear splicing factors, including LSm7. MG132, by inhibiting proteasomal degradation, can lead to an increase in the cellular abundance of splicing factors and related proteins, augmenting the splicing capacity involving LSm7.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
An inhibitor of the exportin 1 (CRM1) nuclear export receptor; it prevents the export of proteins and RNA from the nucleus. By impeding CRM1, it may cause the accumulation of splicing factors, including LSm7, in the nucleus, thus potentially increasing the efficiency of pre-mRNA splicing where LSm7 is crucial. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor; it can change chromatin structure and thereby influence gene expression. This compound can potentially enhance the transcription of genes encoding splicing factors, such as LSm7, by creating a more accessible chromatin state for transcription machinery. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor; it can lead to the hypomethylation of DNA and alter gene expression. It may induce the expression of genes related to RNA processing and splicing, including those associated with the LSm7 protein. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor; similar to Trichostatin A, it can relax chromatin structure to facilitate transcription. It may indirectly upregulate LSm7 by enhancing the transcription of splicing-related genes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A that acts as a ligand for retinoic acid receptors, influencing gene transcription. It can lead to the altered expression of a variety of genes, some of which may encode components of the splicing machinery or interact with such components, thereby potentially affecting LSm7 levels. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
A precursor of vitamin K that serves as a cofactor for the post-translational carboxylation of certain proteins; it can influence gene expression and protein modification. It may affect the expression or function of proteins involved in RNA splicing, potentially impacting LSm7 indirectly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor; it promotes a relaxed chromatin state, potentially increasing the expression of genes involved in RNA processing and splicing, which could include those for LSm7. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor; by preventing protein degradation, it can increase the cellular levels of various proteins, potentially including splicing factors like LSm7, thereby affecting their activity. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
A chemotherapeutic agent that can bind to DNA and interfere with transcription factor binding, potentially altering the expression of genes, including those involved in RNA splicing. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
A molecule that can inhibit the activity of nuclear factor kappa B (NF-κB), which in turn may lead to changes in the expression of genes under NF-κB control, some of which may be involved in RNA processing and, by extension, could affect LSm7. | ||||||