LSm7 Inhibitors
LSm7 inhibitors principally target pathways and processes central to RNA synthesis, metabolism, and maturation. Compounds such as Actinomycin D, α-amanitin, and DRB directly hinder RNA synthesis by binding to DNA or targeting RNA polymerase II. This action invariably results in decreased availability of mRNA substrates for LSm7, which plays a pivotal role in mRNA processing and decay.
On the other hand, a subset of LSm7 inhibitors, including Pladienolide B, Isoginkgetin, and Spliceostatin A, operate by targeting the intricate splicing machinery. These compounds bind to key splicing components, such as the SF3b complex, obstructing the RNA splicing process. LSm7, having a cardinal function in the metabolism of mature mRNAs, has its operations indirectly modulated when splicing dynamics are altered.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
An antibiotic that binds to DNA, preventing RNA synthesis. By inhibiting transcription, Actinomycin D can indirectly affect LSm7's interaction with newly synthesized RNA. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Targets RNA polymerase II, leading to a halt in mRNA synthesis. Reduced mRNA synthesis can lessen the availability of targets for LSm7 processing. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II, thereby affecting mRNA synthesis. The diminished mRNA synthesis can impact LSm7's role in mRNA processing. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Analog of adenosine, and terminates mRNA synthesis once incorporated. This results in a reduction of mRNA transcripts for LSm7 interaction. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, affecting RNA synthesis. Reduced RNA availability can indirectly affect LSm7 processing functions. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Guanosine analog affecting mRNA capping. With defective capping, the processing and stability of mRNAs that LSm7 interacts with can be affected. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Targets the spliceosome, affecting pre-mRNA splicing. LSm7's role in RNA processing can be impacted by alterations in splicing dynamics. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
A biflavonoid that inhibits pre-mRNA splicing. This impacts the generation of mature mRNAs which LSm7 typically interacts with. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Binds to splicing factor SF3b and inhibits splicing. Disruption in splicing can indirectly influence LSm7's RNA processing functions. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Targets the spliceosome, impeding the splicing process. As LSm7 is involved in mRNA processing, disruptions in splicing can affect its function. | ||||||