LRRC50 Activators
LRRC50 Activators comprise a spectrum of chemical entities that augment the functional activity of LRRC50 through modulation of distinct cellular signaling cascades. Forskolin, acting via adenylyl cyclase activation, elevates intracellular cAMP, which in turn activates protein kinase A (PKA). PKA is known to phosphorylate various proteins that could interact with LRRC50, thereby enhancing its role in ciliary motility. Rolipram and IBMX, by inhibiting PDE4 and non-specific phosphodiesterases respectively, result in increased cAMP levels, contributing to PKA-mediated phosphorylation events that could similarly augment LRRC50 function. PGE1, with its adenylate cyclase stimulatory effect, and Epinephrine and Isoproterenol, through beta-adrenergic receptor activation, all raise cAMP levels and activate PKA, leading to potential enhancements in LRRC50 activity related to ciliary dynamics.
Compounds like Sildenafil and Vardenafil operate through the inhibition of PDE5, thus elevating cGMP levels which activate protein kinase G (PKG). PKG could then influence ciliary proteins, potentially enhancing the operational role of LRRC50. In parallel, ANP, by engaging its receptor and elevating intracellular cGMP, also activates PKG, offering another route to potentiate LRRC50's activity in ciliary movement. A23187, a calcium ionophore, increases intracellular calcium concentrations, which could activate calcium-dependent kinases capable of phosphorylating proteins that modulate LRRC50 activity. Lastly, Dibutyryl-cAMP, a synthetic cAMP analog, bypasses cellular receptors and directly activates PKA, offering a direct mechanism to enhance LRRC50's role in the regulation of ciliary movement, showcasing the diverse yet specific ways these activators can synergistically enhance the functionality of LRRC50.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases the intracellular levels of cAMP. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate target proteins that may interact with or modulate the activity of LRRC50, potentially enhancing its function in ciliary movement. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which breaks down cAMP. By inhibiting PDE4, Rolipram indirectly raises cAMP levels, thereby activating PKA and possibly enhancing the activity of LRRC50 in its role within cilia. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases which increases intracellular cAMP levels. The elevation of cAMP could activate PKA, which, in turn, may phosphorylate associated proteins and enhance the activity of LRRC50. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Prostaglandin E1 (PGE1) activates adenylate cyclase, leading to an increase in cAMP and activation of PKA. This activation may enhance the downstream effects on proteins associated with ciliary function, potentially augmenting LRRC50 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors which can activate adenylate cyclase, raising cAMP levels and subsequently activating PKA. PKA may then phosphorylate proteins involved in ciliary motility, enhancing the role of LRRC50. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can activate H2 receptors which couple to adenylate cyclase, increasing cAMP and activating PKA. This may result in the phosphorylation of ciliary proteins, potentially increasing LRRC50 activity within the cilium. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases, which may phosphorylate proteins that interact with LRRC50, potentially augmenting its function in ciliary movement. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analog that directly activates PKA. The activated PKA could then phosphorylate proteins within the cilium, possibly enhancing the activity of LRRC50. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can activate adenylate cyclase, thus increasing cAMP and activating PKA. PKA may enhance the activity of LRRC50 by phosphorylating proteins within the cilium. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
Vardenafil, a PDE5 inhibitor, increases cGMP levels, which can activate PKG. PKG may then modulate ciliary proteins, potentially facilitating an increase in LRRC50 functional activity. | ||||||