LRRC46 Inhibitors
LRRC46 inhibitors Trichostatin A and 5-Azacytidine modulate epigenetic markers such as histone acetylation and DNA methylation, respectively. Changes in these epigenetic states can lead to alterations in gene expression patterns, including potentially the expression of LRRC46. MG132 and Brefeldin A interfere with the ubiquitin-proteasome system and protein trafficking within the cell, respectively, which could affect the stability and localization of LRRC46 or its interacting partners.
Compounds like Chloroquine and Forskolin disrupt endosomal function and cAMP levels, respectively, potentially influencing signaling pathways and cellular processes in which LRRC46 is involved. Genistein, LY294002, and PD98059 are inhibitors that target enzymatic activities such as tyrosine kinases, PI3K, and MEK, respectively. These enzymes play critical roles in signal transduction, and their inhibition can lead to altered cellular responses that may intersect with LRRC46's function or expression. Rapamycin, SB431542, and Z-VAD-FMK influence key regulatory pathways related to cell growth, differentiation, and apoptosis. Rapamycin's inhibition of mTOR, SB431542's targeting of TGF-beta signaling, and Z-VAD-FMK's inhibition of caspases can lead to modifications in cell fate decisions and survival, processes that could implicate LRRC46.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylase (HDAC), potentially affecting gene expression including that of LRRC46. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, it can alter DNA methylation patterns, potentially impacting LRRC46 expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can affect protein degradation pathways, potentially stabilizing proteins that regulate LRRC46. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts protein transport by inhibiting the exchange of protein ADP-ribosylation factor, which could influence LRRC46 trafficking. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Raises endosomal pH, which can affect protein sorting and potentially impact LRRC46 localization or function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase and increases cAMP, which can modulate various signaling pathways possibly linked with LRRC46. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor, which could alter phosphorylation states of proteins interacting with or regulating LRRC46. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, which could disrupt signaling pathways and potentially affect proteins that regulate LRRC46. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which could alter MAPK/ERK pathway activity and subsequently affect LRRC46-related processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, which can influence cell growth and survival pathways possibly involving LRRC46. | ||||||