LOC729966 Inhibitors
LOC729966 inhibitors encompass a variety of compounds that act upon distinct cellular signaling pathways or biological processes potentially linked to the activity of LOC729966. For example, inhibitors such as staurosporine broadly target kinases and could reduce the phosphorylation of proteins within signaling cascades that might be essential for LOC729966 function. The inhibition of PI3K by compounds like LY294002 and wortmannin leads to subsequent decreases in AKT signaling, which could in turn affect the activity of LOC729966 if it is regulated by or dependent on the PI3K/AKT pathway.
The targeting of the mTOR pathway by rapamycin would lead to a decrease in protein synthesis and might affect the levels of proteins that interact with or regulate LOC729966. Similarly, compounds that inhibit the MAPK/ERK pathway, such as U0126 and PD98059, could prevent the activation of proteins that are essential for the proper functioning of LOC729966. Additionally, by inhibiting the JNK pathway with SP600125, transcriptional programs might be altered, potentially impacting LOC729966's functional activity if it is part of this signaling network.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that can inhibit a broad range of kinases involved in numerous signaling pathways. Inhibition of these kinases can lead to a decrease in phosphorylation events that might be necessary for LOC729966 activation or stability. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of PI3K, which is involved in the AKT signaling pathway. Inhibition of PI3K leads to reduced AKT activity, potentially diminishing the phosphorylation and activity of downstream proteins that could interact with or regulate LOC729966. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can suppress the mTORC1 pathway, which is involved in protein synthesis and cell growth. Downregulation of this pathway could result in reduced synthesis of proteins that may be necessary for LOC729966 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor that could prevent the activation of the p38 MAPK pathway. This pathway is implicated in stress responses and inflammation, and its inhibition could decrease the functional activity of proteins that are regulated by stress-activated pathways, potentially including LOC729966. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A MEK1/2 inhibitor that can block the MAPK/ERK pathway, which is involved in cell proliferation and differentiation. Inhibiting this pathway could alter the activity of proteins that require MAPK/ERK signaling for activation, which may encompass LOC729966. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
An irreversible PI3K inhibitor that can lead to diminished AKT signaling. By inhibiting PI3K, wortmannin could reduce the functional activity of proteins downstream of the PI3K/AKT pathway, potentially including LOC729966. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A specific MEK inhibitor that blocks the activation of ERK1/2 in the MAPK pathway. By preventing ERK activation, PD98059 could impair the function of proteins that rely on ERK signaling, possibly affecting LOC729966 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which is involved in apoptosis and cell proliferation. Inhibition of JNK could lead to altered transcriptional programs that affect the function of proteins regulated by JNK signaling, including potentially LOC729966. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that can impede the Rho/ROCK pathway. Inhibition of ROCK leads to altered actin cytoskeleton dynamics and could impact proteins associated with cytoskeletal regulation, potentially influencing LOC729966. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A Src family kinase inhibitor that can block signal transduction involved in cell adhesion, growth, and differentiation. By inhibiting Src kinases, PP2 might indirectly decrease the activity of proteins that are downstream of Src signaling, potentially including LOC729966. | ||||||