LOC729688 Inhibitors
Wortmannin and LY294002, for instance, exert their effects by targeting the PI3K pathway, a critical signaling route that governs cell growth and metabolism. Their inhibition of PI3K can lead to downstream effects, potentially including the modulation of LOC729688 activity. Similarly, Rapamycin acts on the mTOR pathway, a pivotal regulator of cellular growth and proliferation, which may also affect LOC729688 function if it is linked to this pathway. In the context of the MAPK pathway, both SB203580 and PD98059 are selective inhibitors of different kinases within this signaling cascade. SB203580 targets p38 MAP kinase, while PD98059 inhibits MEK1, both potentially altering the signaling events that could determine the activity of LOC729688. The compound SP600125, which inhibits JNK, and the MEK1/2 inhibitor U0126, also function within the MAPK pathway and are capable of modulating the protein's activity, provided that LOC729688 is a downstream target of these pathways.
Further branching into the realm of kinase inhibition, PP2 specifically targets Src family kinases, which are integral to a multitude of cellular processes. The inhibition of Src kinases by PP2 can thus influence the activity of LOC729688. On the other hand, PD0325901, another MEK inhibitor with enhanced bioavailability compared to PD98059, and Ku-55933, an ATM kinase inhibitor, act on the cell cycle and DNA damage response, respectively. These inhibitors could impact LOC729688 function if it is involved in these cellular responses. Lastly, the proteasome inhibitor MG132 and the Aurora kinase inhibitor ZM447439 play roles in protein degradation and mitotic progression, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi and acts as an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, this compound can alter downstream signaling pathways that are crucial for various cellular processes. If LOC729688 is regulated by PI3K signaling, then wortmannin can inhibit its activity indirectly by disrupting the pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, like Wortmannin, is a morpholine derivative that functions as a PI3K inhibitor. By stalling PI3K signaling, LY294002 can modulate downstream pathways that include LOC729688, thereby inhibiting its function within the cell. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a macrolide compound that binds to FKBP12 and inhibits the mechanistic target of rapamycin (mTOR), a key kinase in regulating cell growth and metabolism. If LOC729688 is part of the mTOR signaling pathway, rapamycin can indirectly inhibit its function by halting this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a pyridinyl imidazole derivative known to selectively inhibit p38 MAP kinase. This kinase is involved in inflammatory responses and stress signaling. If LOC729688 is modulated by p38 MAPK, then inhibition by SB203580 can alter its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a synthetic compound that specifically inhibits MEK1, which is upstream of ERK in the MAPK pathway. By inhibiting MEK1, PD98059 can indirectly affect the function of LOC729688 if it is a downstream effector in this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor that targets c-Jun N-terminal kinase (JNK). JNK is involved in the regulation of apoptosis and cell proliferation. If LOC729688 operates downstream of JNK signaling, inhibition by SP600125 can modify its activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a peptide aldehyde that inhibits proteasomes and the ubiquitin-proteasome pathway. If LOC729688 is regulated by proteasomal degradation, MG132 can inhibit this process, thereby affecting the levels and activity of LOC729688. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream activators of ERK in MAPK signaling. By inhibiting MEK activity, U0126 can indirectly influence LOC729688 functions if they are controlled by the MEK/ERK pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. The Src family is involved in controlling various cellular processes, including proliferation and differentiation. If LOC729688 activity is associated with Src signaling, PP2 can inhibit its function. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
Ku-55933 is an inhibitor of ATM kinase, which is activated by DNA damage and involved in cell cycle control. If LOC729688 is regulated by ATM-mediated signaling, Ku-55933 can inhibit its activity. | ||||||