LOC729121 Inhibitors
PI3K inhibitors like Wortmannin and LY294002 exert their influence by obstructing a kinase that serves as a key node in multiple signaling pathways, including those governing cell growth and metabolism. This intervention can alter the phosphorylation pattern and activity of proteins downstream of PI3K, including LOC729121. MEK inhibitor PD98059 and p38 MAPK inhibitor SB203580 target the MAPK signaling pathway, a pivotal regulatory axis for cell proliferation and stress responses, potentially modulating the activity of LOC729121. JNK inhibitor SP600125 and mTOR inhibitor Rapamycin further extend this modulation to stress responses and cellular growth, respectively.
The impact on developmental pathways is represented by chemicals such as Cyclopamine and IWR-1, which target the Hedgehog and Wnt pathways, respectively, signifying how LOC729121's role in cell differentiation and development can be influenced. ZM-447439's inhibition of Aurora kinase and Y-27632's effect on ROCK highlight the potential for altering cell cycle progression and cytoskeletal dynamics. DAPT's engagement with the γ-secretase complex presents an avenue for affecting Notch signaling, which is crucial for cell fate decisions. Lastly, U73122's inhibition of phospholipase C underscores the potential for modifying the intracellular calcium signaling and related pathways.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A specific inhibitor of phosphatidylinositol 3-kinase (PI3K), which can disrupt downstream AKT signaling, thus affecting proteins regulated by this pathway including LOC729121. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor, this chemical can also impede AKT pathway activation, influencing the function or stability of LOC729121 if it is regulated by PI3K/AKT. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A selective inhibitor of mitogen-activated protein kinase kinase (MEK), which can prevent the activation of the extracellular signal-regulated kinase (ERK) pathway that may regulate LOC729121. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A specific inhibitor of p38 MAPK, potentially altering the phosphorylation status and activity of proteins involved in the p38 MAPK signaling pathway, such as LOC729121. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which can change the activity of transcription factors and other proteins that interact with or are regulated by JNK signaling, including LOC729121. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can disrupt protein synthesis and other processes regulated by the mTOR pathway, potentially affecting LOC729121 if it is involved in such processes. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
A Hedgehog signaling pathway inhibitor, which can influence cell differentiation and growth; if LOC729121 is part of this pathway, its activity can be altered. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
An inhibitor of the Wnt signaling pathway, which can affect the stability and localization of proteins associated with Wnt signaling, possibly including LOC729121. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor that can affect cell cycle progression and mitosis; if LOC729121 has a role in these processes, its function can be influenced by this inhibitor. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, which can affect actin cytoskeleton dynamics and cellular contraction; if LOC729121 is linked to these processes, this inhibitor can alter its activity. | ||||||