LOC727992 Inhibitors
Wortmannin and LY294002 are inhibitors of PI3K, an enzyme involved in the PI3K/AKT signaling pathway that is fundamental for many cellular processes, including growth, proliferation, and survival. By inhibiting PI3K, these chemicals can affect proteins regulated by this pathway. Rapamycin specifically inhibits mTOR, a central protein in the cellular growth and nutrient sensing pathway, influencing proteins that are controlled by mTOR signaling. SP600125 and SB203580 target the stress-activated JNK and p38 MAP kinase respectively, which are pathways involved in inflammation, apoptosis, and cell differentiation. Inhibition of these kinases can lead to changes in the regulation of proteins associated with these pathways. ZM-447439 disrupts the function of Aurora kinases, which play a key role in cell division, thus potentially affecting proteins involved in mitosis.
Trichostatin A and PD0332991 act on epigenetic and cell cycle regulators, respectively. Trichostatin A changes gene expression by inhibiting histone deacetylases, while PD0332991 targets CDK4/6 to halt the cell cycle. U0126 prevents the activation of the MEK1/2, thereby influencing the MAPK/ERK signaling cascade. Ibrutinib, Olaparib, and ABT-199 inhibit Bruton's tyrosine kinase, PARP, and Bcl-2, respectively. Each of these enzymes is involved in crucial cellular pathways: Ibrutinib affects B cell receptor signaling, Olaparib hinders DNA repair, and Venetoclax induces apoptosis, each altering the regulation and function of proteins associated with their respective pathways.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
An inhibitor of phosphoinositide 3-kinases (PI3K), which can affect proteins regulated by the PI3K/Akt pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which can affect protein synthesis and cell growth, potentially influencing proteins that are downstream of mTOR signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which can alter apoptosis and other cellular processes, potentially affecting proteins regulated by JNK signaling. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor, which can disrupt cell division and therefore potentially affect proteins that are involved in the cell cycle. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor, which can change gene expression patterns and potentially affect proteins regulated by chromatin remodeling. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
A cyclin-dependent kinase inhibitor (CDK4/6), which can halt cell cycle progression, potentially influencing proteins involved in cell cycle regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAP kinase inhibitor, which can modulate inflammatory responses and cell differentiation, potentially affecting proteins in the p38 MAPK pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An inhibitor of MEK1/2, which can prevent the activation of MAPK/ERK pathway, potentially impacting proteins downstream of this signaling cascade. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Another PI3K inhibitor that can suppress the PI3K/AKT signaling pathway, potentially influencing proteins involved in survival and metabolism. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $156.00 | 5 | |
A Bruton's tyrosine kinase inhibitor, which can affect B cell receptor signaling, potentially impacting proteins involved in this pathway. | ||||||