LOC643933 Activators
Forskolin and IBMX raise the levels of cAMP, a second messenger with extensive roles in cellular signaling, thereby affecting the functional state of proteins responsive to cAMP. Genistein and PD98059, by interfering with tyrosine kinase signaling and MEK activity respectively, have the potential to alter the activity of proteins within those pathways.
LY294002 and Wortmannin serve as PI3K inhibitors, disrupting a key pathway involved in regulating cell growth and survival, which can have wide-ranging implications for proteins downstream of PI3K/Akt signaling. U0126 and SB203580, by inhibiting MEK and p38 MAPK respectively, can induce changes in proteins that are regulated by the MAPK/ERK and p38 MAPK pathways, which are critical in controlling cell differentiation, proliferation, and response to stress. Rapamycin's inhibition of mTOR signaling can affect protein synthesis and autophagy, thereby modulating proteins involved in cellular metabolism and growth. KN-93, by targeting CaMKII, can influence proteins that are regulated by calcium/calmodulin-dependent processes. NF449's selective inhibition of the Gsα-subunit of G-proteins can impact proteins that are regulated by G-protein-coupled receptor signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which prevents cAMP degradation, potentially enhancing the activity of cAMP-dependent proteins. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor that can alter cellular signaling pathways, indirectly affecting protein function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, which is part of the MAPK/ERK pathway, potentially affecting downstream protein activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A potent inhibitor of the PI3K/Akt pathway, which can influence numerous proteins involved in cell survival and metabolism. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Another inhibitor of MEK, which can lead to changes in the proteins regulated by the MAPK/ERK signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor, potentially influencing proteins associated with inflammatory responses and stress signals. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, modulating proteins involved in apoptosis and other cellular processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent PI3K inhibitor that can affect downstream protein activity within the PI3K/Akt pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Binds to mTOR and inhibits its activity, potentially affecting the activity of proteins involved in cell growth and proliferation. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
An inhibitor of CaMKII, which can modulate proteins that are regulated by calcium/calmodulin-dependent processes. | ||||||