LOC643714 Inhibitors
Staurosporine is a well-known kinase inhibitor with a broad spectrum of activity that can impede various kinase-mediated signal transduction events that LOC643714 may be a part of. PI3K/AKT signaling is crucial for numerous cellular functions, including growth, proliferation, and survival. LY294002 is a chemical that can interrupt this pathway, thereby potentially affecting the activity of LOC643714. Similarly, the MEK-ERK pathway is another significant signaling cascade, and U0126's inhibition of MEK can prevent the phosphorylation of ERK, which in turn could influence LOC643714.
TGF-β signaling is a critical pathway in cell differentiation and apoptosis, and SB431542's inhibition of ALK5 suggests a mechanism by which it can impact the functions associated with LOC643714. Src family kinases, targeted by PP2, are involved in various cellular processes, including migration, invasion, and proliferation, whereby inhibiting these kinases can alter the signaling milieu of LOC643714. Further, the JNK and Aurora kinase pathways, inhibited by SP600125 and ZM-447439 respectively, play roles in stress response and cell cycle regulation. Disruption of these pathways can influence cellular outcomes that are potentially governed by LOC643714. MG132's role in inhibiting the proteasome affects the degradation of cellular proteins, which could be crucial for the modulation of LOC643714's stability and function.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can inhibit multiple kinase-dependent signaling pathways affecting LOC643714. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can disrupt the PI3K/AKT pathway, potentially influencing LOC643714 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A MEK inhibitor that can prevent ERK phosphorylation, which may be involved in signaling related to LOC643714. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An ALK5 inhibitor that can impede TGF-β signaling, which may intersect with LOC643714's function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A selective Src family kinase inhibitor that can alter downstream signaling involving LOC643714. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that can affect cellular stress and apoptosis pathways linked with LOC643714. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
An FGFR inhibitor that can block pathways associated with cell proliferation and possibly LOC643714. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that can interfere with cytoskeleton organization and processes involving LOC643714. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can impact protein degradation and turnover pathways of LOC643714. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
A potent Gsα subunit inhibitor that can disrupt G protein-coupled receptor signaling related to LOC643714. | ||||||