LOC100130705 Activators
Chemical activators of LOC100130705 can initiate a cascade of intracellular events leading to the phosphorylation and subsequent activation of the protein. Forskolin acts by increasing intracellular cAMP levels which then activate protein kinase A (PKA). PKA directly phosphorylates LOC100130705, enhancing its activity within cAMP-dependent signaling pathways. Similarly, PMA, a diacylglycerol analog, activates protein kinase C (PKC), which phosphorylates a wide range of substrates including LOC100130705, thereby modulating its function. Ionomycin, by increasing intracellular calcium levels, activates calcium-sensitive kinases such as CaMKII. CaMKII-mediated phosphorylation serves as another route to LOC100130705 activation. Calyculin A and Okadaic Acid, both phosphatase inhibitors, contribute to LOC100130705 activation by inhibiting the dephosphorylation of the protein, thereby maintaining it in an activated state.
Other chemicals act on similar pathways with varying mechanisms. Anisomycin activates stress-activated protein kinases like JNK and p38 MAPK, which then phosphorylate LOC100130705 as part of the cellular response to stress. Thapsigargin by inhibiting the SERCA pump also raises cytosolic calcium levels, triggering calcium-dependent kinases to activate LOC100130705. 1,2-Dioctanoyl-sn-glycerol functions as a synthetic analog to diacylglycerol, activating PKC and thus promoting phosphorylation of LOC100130705. A23187, a calcium ionophore, elevates intracellular calcium, which in turn can activate kinases that phosphorylate LOC100130705. Finally, BIM, while a PKC inhibitor, can lead to the compensatory activation of alternative kinases, resulting in the phosphorylation and activation of LOC100130705. Each of these chemicals, through their respective signaling pathways, ensures that LOC100130705 is phosphorylated and activated, integrating it into various cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC which is known to phosphorylate a wide range of target proteins. PKC-mediated phosphorylation specifically activates LOC100130705 by modulating its function as part of signal transduction pathways that LOC100130705 is involved in. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-sensitive signaling molecules. This rise in calcium can activate kinases such as CaMKII, which then phosphorylate and activate LOC100130705 as part of calcium-mediated signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits protein phosphatases like PP1 and PP2A, leading to the accumulation of phosphorylated proteins within the cell. This inhibition can result in the sustained activation of LOC100130705 due to a reduction in the dephosphorylation rate of the protein. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is an activator of the stress-activated protein kinases such as JNK and p38 MAPK. Activation of these kinases leads to phosphorylation and activation of downstream proteins, including LOC100130705, as part of the cellular response to stress signals. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the SERCA pump, leading to an increase in cytosolic calcium levels. This increase can activate calcium-dependent kinases that may phosphorylate and activate LOC100130705 as part of intracellular calcium signaling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, similar to Okadaic Acid, inhibits phosphatases PP1 and PP2A. This inhibition prevents the dephosphorylation of proteins, potentially leading to the prolonged activation of LOC100130705 through phosphorylation. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a CaMKII inhibitor, but by inhibiting CaMKII, it can cause compensatory activation of other kinases in calcium signaling pathways, which may lead to the phosphorylation and activation of LOC100130705. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
This synthetic diacylglycerol analog acts as a PKC activator, mimicking the action of diacylglycerol in signal transduction. PKC activation can lead to the phosphorylation and activation of LOC100130705 as part of the protein's involvement in diacylglycerol-PKC signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, which can activate calcium-dependent signaling pathways. This can lead to the activation of kinases that phosphorylate and activate LOC100130705, integrating it into calcium-dependent signaling processes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM is a PKC inhibitor, but it can also activate signaling pathways compensatorily. This may result in the activation of kinases that are part of the signaling pathways in which LOC100130705 is involved, leading to its phosphorylation and functional activation. | ||||||