LOC100128731 Activators
Chemical activators of LOC100128731 can initiate a cascade of intracellular events leading to its activation. The process often begins with the alteration of intracellular calcium levels, as seen with chemicals like Calcium ionophore A23187 and Ionomycin. These agents increase intracellular calcium concentrations, which then activate calcium-dependent protein kinases. These kinases can directly phosphorylate LOC100128731, thereby activating the protein. Similarly, Thapsigargin disrupts calcium storage within the endoplasmic reticulum, leading to a rise in cytosolic calcium levels, which in turn activates calcium-dependent kinases capable of phosphorylating LOC100128731. This phosphorylation changes the conformation of LOC100128731, effectively activating it.
Additionally, various other chemical activators operate through modulating kinase activity. For instance, Forskolin activates adenylyl cyclase, which increases the levels of cAMP within the cell. This surge in cAMP levels leads to the activation of protein kinase A (PKA), which can phosphorylate and activate LOC100128731. Phorbol 12-myristate 13-acetate (PMA) and 4-Phorbol function by activating protein kinase C (PKC), which is known to target a broad range of proteins for phosphorylation, including LOC100128731, resulting in its activation. Dibutyryl-cyclic AMP (db-cAMP), a synthetic analog of cAMP, similarly activates PKA, which then can phosphorylate LOC100128731. Okadaic acid and Calyculin A inhibit protein phosphatases, which normally dephosphorylate proteins, thereby leading to a net increase in phosphorylated LOC100128731, maintaining it in an activated state. Anisomycin, by activating stress-activated protein kinases, can also lead to the phosphorylation and consequent activation of LOC100128731. Lastly, Isoproterenol, through its action on the beta-adrenergic receptors, triggers an increase in adenylyl cyclase activity, thus raising cAMP levels, activating PKA, and subsequently leading to the phosphorylation and activation of LOC100128731.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium concentrations, which activates calcium-dependent protein kinases that can phosphorylate LOC100128731, leading to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which is known to phosphorylate various substrates that could include LOC100128731, thus leading to its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium concentrations, which can activate calcium-dependent protein kinases that are capable of phosphorylating LOC100128731, activating the protein. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases, leading to sustained phosphorylation. This effect can result in the activation of LOC100128731 through phosphorylation by kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cAMP analog that activates PKA. PKA then phosphorylates targets including LOC100128731, which can result in activation of the protein. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium storage and increases intracellular calcium levels, which could activate calcium-dependent protein kinases that phosphorylate and activate LOC100128731. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I, although typically a PKC inhibitor, can under certain conditions lead to the activation of specific PKC isoforms, which may phosphorylate and activate LOC100128731. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases, which can phosphorylate LOC100128731, leading to its activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like okadaic acid, inhibits protein phosphatases, which can result in sustained phosphorylation of proteins including LOC100128731, thereby activating it. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
4-Phorbol activates specific isoforms of PKC, which in turn can phosphorylate LOC100128731, resulting in its activation. | ||||||