LOC100041438 Inhibitors
LOC100041438 inhibitors may contain compounds like Wortmannin and LY294002 inhibit the activity of phosphoinositide 3-kinases (PI3K), thereby potentially affecting proteins regulated by PI3K-dependent pathways. Triciribine and Rapamycin serve as inhibitors of the Akt and mTOR pathways respectively, both of which are crucial in cell survival, proliferation, and growth signals that could intersect with the functions of LOC100041438.
Other inhibitors like U0126 and PD98059 target the MAPK/ERK pathway, a key signaling cascade that can control a wide range of cellular activities including proliferation, differentiation, and response to cellular stress. SB203580 and SP600125 are inhibitors of p38 MAPK and JNK, respectively, and can modulate cellular responses to cytokines and stress. Bortezomib and MG132 are proteasome inhibitors that prevent the degradation of proteins, thereby potentially influencing the levels and activity of a broad spectrum of proteins within the cell, including LOC100041438. Z-VAD-FMK, as a pan-caspase inhibitor, can impact apoptosis, which might be relevant to the function of LOC100041438 if it is involved in cell death pathways. Thapsigargin disrupts calcium homeostasis by inhibiting endoplasmic reticulum calcium pumps, which can lead to a cascade of cellular events affecting numerous proteins and processes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A steroidal metabolite inhibitor of phosphoinositide 3-kinases, can suppress downstream signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A synthetic molecule that inhibits PI3K, can halt signaling cascades that may involve LOC100041438. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
A synthetic nucleoside analog, inhibits Akt, potentially affecting proteins regulated by the Akt pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A pyridinyl imidazole derivative, inhibits p38 MAPK, and can alter stress response pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A synthetic compound that selectively inhibits MEK, which may regulate proteins downstream of MEK. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
A macrolide compound that inhibits mTOR, which can modulate cell growth and proliferation signals. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of JNK, can alter apoptosis and other cellular processes involving JNK signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, can affect protein degradation pathways, potentially influencing protein levels indirectly. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A peptide aldehyde that inhibits proteasomes, can lead to increased levels of certain regulatory proteins. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
A cell-permeable, irreversible pan-caspase inhibitor, can affect apoptotic processes. | ||||||