LIN-35 Inhibitors
Chemical inhibitors of LIN-35 can influence the protein's function by targeting the histone deacetylases (HDACs) that modulate chromatin structure, which is pivotal for the transcriptional repression activities of LIN-35. Trichostatin A, Vorinostat, Romidepsin, Panobinostat, Entinostat, Belinostat, and Valproic Acid are all HDAC inhibitors that increase the acetylation level of histones. This hyperacetylated state of histones is associated with a more relaxed chromatin structure, which can inhibit the ability of LIN-35 to repress the transcription of its target genes. For instance, Trichostatin A can alter chromatin accessibility, preventing LIN-35 from exerting its repressive effects efficiently. Similarly, Vorinostat and Romidepsin can disrupt the interaction between LIN-35 and the chromatin, thereby inhibiting the LIN-35-mediated transcriptional repression.
Further, chemicals like Mocetinostat, Chidamide, AR-42, and Givinostat also act as HDAC inhibitors, but with varying specificity towards different classes of HDACs. Mocetinostat's action on Class I and IV HDACs, and Chidamide's selective inhibition of HDACs, can lead to an increase in acetylated histones, which opposes the transcriptional repression activity of LIN-35 by changing the chromatin landscape. AR-42, through its HDAC inhibitory action, can similarly create a chromatin environment that is not favorable for LIN-35's function. Givinostat's role in increasing histone acetylation supports the formation of a chromatin structure that inhibits LIN-35's ability to compact the chromatin and repress gene expression. Each of these chemicals, by modulating the acetylation status of histones, can influence the chromatin structure in a way that inhibits the function of LIN-35 as a transcriptional repressor.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase (HDAC), which leads to an increase in acetylated histones. This can inhibit LIN-35 by altering the chromatin structure and thereby reducing the ability of LIN-35 to repress transcription of its target genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, another HDAC inhibitor, would similarly lead to increased acetylation of histones, potentially disrupting LIN-35 mediated transcriptional repression by changing the chromatin structure. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin functions as an HDAC inhibitor and could inhibit LIN-35 by preventing the deacetylation of histones, thereby maintaining a chromatin structure less conducive to LIN-35 mediated transcriptional repression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
As an HDAC inhibitor, Panobinostat would increase histone acetylation, which may counteract the transcriptional repression usually facilitated by LIN-35 by altering chromatin accessibility. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat selectively inhibits Class I HDACs, leading to increased acetylation of histones and potentially inhibiting LIN-35's ability to repress transcription by changing chromatin structure. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat is an HDAC inhibitor that could inhibit LIN-35 by maintaining acetylated histones, resulting in a chromatin state that opposes LIN-35's role in transcriptional repression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, an HDAC inhibitor, could diminish LIN-35 repression by increasing histone acetylation, which changes the chromatin structure. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat inhibits Class I and IV HDACs, potentially disrupting LIN-35 mediated transcriptional repression by altering the chromatin structure through increased histone acetylation. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide is an HDAC inhibitor that may inhibit LIN-35 by promoting a chromatin structure that is not conducive to the transcriptional repression normally facilitated by LIN-35. | ||||||
(S)-HDAC-42 | 935881-37-1 | sc-296364 sc-296364A | 1 mg 5 mg | $94.00 $409.00 | ||
AR-42 is an HDAC inhibitor that could inhibit LIN-35 by increasing histone acetylation, leading to chromatin remodeling that opposes LIN-35's transcriptional repression activity. | ||||||