LIMP III Inhibitors
Chemical inhibitors of LIMP III include a variety of compounds that interact with cellular cholesterol, which is integral to the function of LIMP III in intracellular cholesterol transport and lysosomal function. Cholesterol itself, when incorporated into cell membranes, can alter the membrane's physical properties, impairing membrane-associated proteins such as LIMP III. Similarly, Methyl-β-cyclodextrin can inhibit LIMP III by extracting cholesterol from the plasma membrane, which is known to disrupt lipid rafts and potentially impair the proper localization and function of LIMP III. Filipin, which binds cholesterol within the plasma membrane, can disrupt cholesterol-rich domains essential for the proper functioning of LIMP III, especially in membrane trafficking and lysosomal activities.
Further, a series of statins including Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin, and Pitavastatin, act as inhibitors of HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis. By inhibiting this enzyme, these statins can decrease the cholesterol levels in cellular membranes, which can inhibit LIMP III by impacting its cholesterol-related activities and its role in the maintenance of cholesterol homeostasis within cellular compartments. U18666A, a compound known to alter intracellular cholesterol distribution, can inhibit LIMP III by affecting the lysosomal localization and function, impairing the endosomal-lysosomal pathways where LIMP III is involved. Nystatin and Amphotericin B, both of which bind to sterols in membranes, can inhibit LIMP III by disrupting membrane integrity and thereby affecting LIMP III's role in membrane fusion events, essential for lysosomal functioning and enzyme trafficking. These chemical inhibitors collectively target the cholesterol-dependent functions of LIMP III, thereby leading to inhibition of its role in cellular cholesterol management and transport mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Cholesterol can inhibit LIMP III by incorporating into cell membranes and potentially altering the membrane's physical properties, which can impair membrane-associated proteins like LIMP III from functioning in intracellular cholesterol transport. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Methyl-β-cyclodextrin can inhibit LIMP III by extracting cholesterol from the plasma membrane, disrupting lipid rafts where LIMP III is localized, thus impairing its function in membrane dynamics and endosomal sorting. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin binds to cholesterol within the plasma membrane, which can inhibit LIMP III by disrupting the cholesterol-rich domains that are crucial for LIMP III's function in membrane trafficking and lysosomal function. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A can inhibit LIMP III by altering intracellular cholesterol distribution, affecting the lysosomal localization and function of LIMP III in cholesterol trafficking and potentially impairing its ability to mediate endosomal-lysosomal pathways. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin can inhibit LIMP III by inhibiting HMG-CoA reductase, leading to reduced synthesis of cholesterol and potentially impacting the cholesterol-dependent functions of LIMP III in intracellular cholesterol homeostasis. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin inhibits HMG-CoA reductase, potentially leading to a decrease in cholesterol levels in cellular membranes, which can inhibit LIMP III by affecting its cholesterol-related activities in the lysosomal and endosomal pathways. | ||||||
Pravastatin, Sodium Salt | 81131-70-6 | sc-203218 sc-203218A sc-203218B | 25 mg 100 mg 1 g | $68.00 $159.00 $772.00 | 2 | |
Pravastatin inhibits HMG-CoA reductase, which can lead to altered cholesterol biosynthesis and membrane composition, potentially inhibiting LIMP III's function in cholesterol transport and lysosomal enzyme trafficking. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $252.00 $495.00 | 9 | |
Atorvastatin inhibits HMG-CoA reductase, potentially decreasing membrane cholesterol and inhibiting LIMP III by impacting its role in the maintenance of cholesterol homeostasis within cellular compartments. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $142.00 | 8 | |
Rosuvastatin can inhibit LIMP III by inhibiting HMG-CoA reductase, potentially decreasing cholesterol levels in membranes and affecting LIMP III's function in cholesterol trafficking and lysosomal enzyme transport. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Nystatin binds to ergosterol and cholesterol, which can inhibit LIMP III by disrupting membrane integrity and affecting LIMP III's role in membrane fusion events and lysosomal functioning. | ||||||