LHX4 Activators
The class of LHX4 activators consists of chemicals that indirectly influence the activity of this transcription factor by modulating various cellular signaling pathways. These compounds work through different mechanisms, thereby affecting LHX4's role in developmental processes and gene expression. Compounds like Retinoic Acid, β-Catenin Stabilizers (e.g., BIO), Dorsomorphin, Lithium Chloride, IWR-1, SB431542, Cyclopamine, and CHIR99021 modulate crucial developmental signaling pathways, including retinoic acid, Wnt/β-catenin, BMP, TGF-β, and Hedgehog pathways. By impacting these pathways, these compounds can indirectly influence LHX4 activity, given its role in developmental processes.
Other chemicals, such as Forskolin, PD98059, Y-27632, and U0126, operate through different mechanisms. Forskolin raises cAMP levels, potentially impacting LHX4 through cAMP-dependent signaling. PD98059 and U0126 are MEK inhibitors, influencing LHX4 activity via the MAPK/ERK pathway. Y-27632, a ROCK inhibitor, can affect LHX4 by altering cytoskeletal dynamics. Together, these chemicals provide a diverse approach to modulating LHX4 activity, highlighting the intricate network of signaling pathways that regulate transcription factors and their roles in development and gene expression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene expression; can impact LHX4 activity via retinoic acid signaling pathways. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
BMP signaling inhibitor; can influence LHX4 through BMP pathway modulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, affecting Wnt/β-catenin signaling; can indirectly impact LHX4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP levels; can influence LHX4 via cAMP-dependent pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor; can modulate LHX4 activity by impacting the MAPK/ERK pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
Wnt pathway inhibitor; can affect LHX4 activity via Wnt signaling modulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β signaling inhibitor; can influence LHX4 activity through TGF-β pathway modulation. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Hedgehog pathway inhibitor; can impact LHX4 through Hedgehog signaling modulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor; can influence LHX4 activity by affecting cytoskeletal dynamics. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3β inhibitor; can modulate LHX4 activity via Wnt/β-catenin signaling. | ||||||