LHX4 Antibody (E-10): sc-374562
- LHX4 Antibody (E-10) is a mouse monoclonal IgG1 κ LHX4 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against a peptide mapping near the C-terminus of LHX4 of human origin
- LHX4 Antibody (E-10) is recommended for detection of LHX4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-374562 X, 200 µg/0.1 ml)
- Anti-LHX4 Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LHX4 Antibody (E-10) for WB applications. These reagents are now offered in bundles with LHX4 Antibody (E-10) (see ordering information below).
LHX4 Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects LHX4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LHX4 Antibody (E-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LHX4, a member of the LIM homeodomain transcription factor family, plays a crucial role in pituitary gland development and is essential for proper organismal differentiation. LHX4′s LIM domain, characterized by a zinc finger structure, facilitates protein-protein interactions vital for various cellular processes, including gene expression regulation during embryonic development. LHX4 is predominantly expressed in murine fetal brain, spinal cord, and cerebral cortex, and continues expression in adult central nervous system, particularly in motor neurons. Mutations in LHX4 can lead to significant developmental disorders, such as short stature and defects in pituitary and cerebellar regions, highlighting LHX4′s importance in normal growth and development. Human LHX4, located on chromosome 1q25, encodes a 390 amino acid protein and has been implicated in acute lymphoblastic leukemia through expression in leukemic cells, suggesting a potential role in leukemogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LHX4 Antibody (E-10) References:
- The LIM domain: regulation by association. | Bach, I. 2000. Mech Dev. 91: 5-17. PMID: 10704826
- [LIM homeobox genes family in nervous system]. | Chen, B., et al. 1997. Sheng Li Ke Xue Jin Zhan. 28: 24-8. PMID: 10921073
- Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. | Machinis, K., et al. 2001. Am J Hum Genet. 69: 961-8. PMID: 11567216
- cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. | Liu, Y., et al. 2002. Brain Res. 928: 147-55. PMID: 11844481
- A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4. | Kawamata, N., et al. 2002. Oncogene. 21: 4983-91. PMID: 12118377
- Multistep control of pituitary organogenesis. | Sheng, HZ., et al. 1997. Science. 278: 1809-12. PMID: 9388186
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LHX4 Antibody (E-10) | sc-374562 | 200 µg/ml | $316.00 | |||
LHX4 Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-527479 | 200 µg Ab; 10 µg BP | $354.00 | |||
LHX4 Antibody (E-10): m-IgG1 BP-HRP Bundle | sc-532852 | 200 µg Ab; 20 µg BP | $354.00 | |||
LHX4 Antibody (E-10) X | sc-374562 X | 200 µg/0.1 ml | $316.00 | |||
LHX4 Antibody (E-10) AC | sc-374562 AC | 500 µg/ml, 25% agarose | $416.00 | |||
LHX4 Antibody (E-10) HRP | sc-374562 HRP | 200 µg/ml | $316.00 | |||
LHX4 Antibody (E-10) FITC | sc-374562 FITC | 200 µg/ml | $330.00 | |||
LHX4 Antibody (E-10) PE | sc-374562 PE | 200 µg/ml | $343.00 | |||
LHX4 Antibody (E-10) Alexa Fluor® 488 | sc-374562 AF488 | 200 µg/ml | $357.00 | |||
LHX4 Antibody (E-10) Alexa Fluor® 546 | sc-374562 AF546 | 200 µg/ml | $357.00 | |||
LHX4 Antibody (E-10) Alexa Fluor® 594 | sc-374562 AF594 | 200 µg/ml | $357.00 | |||
LHX4 Antibody (E-10) Alexa Fluor® 647 | sc-374562 AF647 | 200 µg/ml | $357.00 | |||
LHX4 Antibody (E-10) Alexa Fluor® 680 | sc-374562 AF680 | 200 µg/ml | $357.00 | |||
LHX4 Antibody (E-10) Alexa Fluor® 790 | sc-374562 AF790 | 200 µg/ml | $357.00 | |||
LHX4 (E-10) Neutralizing Peptide | sc-374562 P | 100 µg/0.5 ml | $68.00 |