LCA5 Inhibitors
Chemical inhibitors of LCA5 function through various mechanisms to disrupt the normal biological processes where LCA5 is a pivotal component. Miconazole, by interacting with the enzyme 14-alpha demethylase, hinders sterol synthesis, which is vital for maintaining cellular membrane composition. Such alterations in the membrane can adversely affect LCA5 function, given its localization and role in cilia. Similarly, trifluoperazine impedes calmodulin-dependent processes. Given that calmodulin plays a crucial role in regulating ciliary beat frequency and hence ciliary function, the presence of trifluoperazine can result in the inhibition of LCA5. Genistein targets tyrosine kinases that are integral to cellular signaling pathways, including those that govern the functions of cilia, thereby potentially inhibiting LCA5. Chlorpromazine, by inhibiting dopamine receptors, can also affect ciliary beat and thereby LCA5 function.
Inhibition of LCA5 can also occur through interference with the actin and microtubule components of the cytoskeleton. Compounds like wiskostatin, latrunculin A, and cytochalasin D disrupt actin dynamics, which are essential for the assembly and maintenance of cilia, where LCA5 is localized. Wiskostatin inhibits the N-WASP, latrunculin A binds to actin monomers, and cytochalasin D binds to the barbed ends of actin filaments, all preventing proper polymerization and thus potentially inhibiting LCA5. On the other hand, colchicine, nocodazole, and griseofulvin perturb the function of tubulin, a key component of microtubules that form the ciliary structure. Colchicine binds to tubulin, preventing its polymerization, nocodazole binds to beta-tubulin and inhibits microtubule polymerization, and griseofulvin disrupts microtubule function by binding to tubulin, all of which can result in the inhibition of LCA5. Paclitaxel, although it stabilizes microtubules, can also disrupt microtubule dynamics necessary for cilia function, therefore, indirectly causing inhibition of LCA5. Lastly, harmine inhibits the kinase DYRK1A, which may be involved in pathways regulating ciliary function, thus its action may lead to the inhibition of LCA5.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $66.00 $160.00 | 2 | |
Miconazole interacts with 14-alpha demethylase, an enzyme involved in sterol synthesis. LCA5 is implicated in ciliogenesis, and disruption of sterol synthesis can alter cellular membrane composition, potentially inhibiting LCA5 function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits tyrosine kinases which are critical for various signaling pathways including those regulating ciliary processes, where LCA5 is localised, thus its inhibition can disrupt LCA5-related functions. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine inhibits dopamine receptors and has been shown to disrupt ciliary beat frequency. As LCA5 is associated with cilia, its inhibition through altered dopaminergic signaling can inhibit LCA5-associated processes. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an inhibitor of the N-WASP which is involved in actin polymerization. Since LCA5 is associated with cilia and ciliary assembly is actin-dependent, wiskostatin can inhibit LCA5 by disrupting actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, which is essential for cilia formation. By disrupting actin dynamics, Latrunculin A can inhibit LCA5 function in ciliary assembly and maintenance. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed end of actin filaments, preventing elongation. This action can inhibit LCA5 by disrupting the cytoskeletal organization required for the proper function of cilia where LCA5 is localized. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization, which is necessary for cilia formation and function. Inhibiting tubulin dynamics can therefore inhibit LCA5 function indirectly through impeding ciliary assembly. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule networks by binding to beta-tubulin and inhibiting polymerization. As microtubules are crucial for ciliary structure, Nocodazole can inhibit LCA5 function by impairing cilia formation and function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, and since LCA5 is associated with ciliary function, its inhibition can result from altered microtubule dynamics which are crucial for cilia stability. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Harmine is known to inhibit DYRK1A, a kinase that phosphorylates various substrates involved in neurogenesis and may play a role in ciliary function. Inhibition of DYRK1A can lead to downstream inhibition of LCA5 function. | ||||||