Layilin Activators
Layilin Activators encompass a range of chemical compounds that indirectly enhance its functional activity, particularly in cell adhesion and cytoskeletal organization. For instance, Forskolin, by boosting intracellular cAMP levels, indirectly augments Layilin's role in cell adherence through the activation of PKA, which influences the phosphorylation of proteins integral to cytoskeletal arrangement. Similarly, PMA, as an activator of PKC, and Sphingosine-1-phosphate, through G protein-coupled receptor signaling, both contribute to Layilin's engagement in cytoskeletal dynamics. Genistein, by inhibiting competitive tyrosine kinase signaling, allows Layilin to more actively participate in cellular adhesion processes. Furthermore, agents like LY294002 and Wortmannin, by inhibiting PI3K, and EGCG, as a broader kinase inhibitor, enhance Layilin's function by attenuating pathways that normally suppress its involvement in cell adhesion and motility.
Further modulation of Layilin's activity is achieved through chemicals that influence intracellular calcium levels and MAPK signaling. Thapsigargin and A23187 serve to elevate calcium levels, which indirectly enhances Layilin's participation in cell morphology and adhesion processes. On the other hand, U0126 and SB203580, which inhibit MEK and p38 MAPK respectively, shift the cellular signaling balance to favor Layilin's pathways. Staurosporine, despite being a broad-spectrum kinase, selectively enhances Layilin's pathways by inhibiting kinases that negatively regulate its related signaling. Collectively, these chemical activators, through their targeted effects on cellular signaling, facilitate the enhancement of Layilin-mediated functions, particularly those involving the complex interplay of the cell's structural and signaling frameworks that ultimately dictate cell shape, adhesion, and motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is known to raise levels of cyclic AMP (cAMP) which can enhance Layilin activity since cAMP-dependent protein kinase (PKA) phosphorylation can lead to cytoskeletal rearrangements, affecting Layilin's role in cell adhesion. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC) which is involved in modulating cytoskeletal organization. Layilin, being associated with the cytoskeleton, would have enhanced activity due to PKC-mediated signaling pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that acts through G protein-coupled receptors to influence cytoskeletal dynamics and cell adhesion, processes in which Layilin is directly implicated. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates intracellular calcium levels, activating calcium-dependent signaling pathways. Layilin activity is modulated by calcium signaling, which is crucial for its role in cell morphology. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can enhance Layilin activity by reducing competitive tyrosine kinase signaling, which indirectly affects the protein's role in the cellular matrix and adhesion. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which can upregulate pathways where Layilin is involved by reducing PI3K/Akt signaling that normally inhibits processes related to cell adhesion and migration. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that can enhance Layilin-mediated signaling by reducing competitive kinase activity, thus promoting processes of cell adhesion where Layilin is active. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor which can lead to the selective activation of Layilin pathways by inhibiting kinases that normally suppress Layilin-related signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK which can upregulate Layilin activity by reducing p38 MAPK signaling that competes with Layilin-associated pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as an ionophore that increases intracellular calcium levels, thus potentially enhancing Layilin's activity by promoting calcium-dependent signaling pathways important for cell morphology. | ||||||