Layilin Antibody (C-7): sc-377389
- Layilin Antibody (C-7) is a mouse monoclonal IgG1 κ Layilin antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 251-382 mapping within a C-terminal cytoplasmic domain of Layilin of human origin
- Layilin Antibody (C-7) is recommended for detection of Layilin of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Layilin Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Layilin Antibody (C-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Layilin Antibody (C-7) (see ordering information below).
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Layilin Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Layilin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Layilin (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Layilin is a vital integral membrane hyaluronan receptor that plays a significant role in cell adhesion and motility, primarily by interacting with the ERM (ezrin, radixin, moesin) protein family, which serves as a crucial link between the cytoskeleton and cell membrane. This interaction is essential for maintaining the cortical structure of the cell, as Layilin mediates signals from the extracellular matrix to the cytoskeleton, facilitating various cellular processes. Notably, in spreading cells, Layilin acts as a membrane-binding site for talin in the peripheral ruffles, which is critical for the migration of cells to wound sites, thereby underscoring Layilin′s importance in tissue repair and regeneration. Anti-Layilin antibody (C-7) versatility in various applications makes this product an invaluable tool for researchers studying cell dynamics and the underlying mechanisms of cell adhesion and migration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Layilin Antibody (C-7) References:
- Layilin, a novel integral membrane protein, is a hyaluronan receptor. | Bono, P., et al. 2001. Mol Biol Cell. 12: 891-900. PMID: 11294894
- Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. | Weng, L., et al. 2002. Genomics. 80: 62-70. PMID: 12079284
- Isolation and characterization of chondrolectin (Chodl), a novel C-type lectin predominantly expressed in muscle cells. | Weng, L., et al. 2003. Gene. 308: 21-9. PMID: 12711387
- Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. | Bono, P., et al. 2005. Exp Cell Res. 308: 177-87. PMID: 15913605
- Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. | Hirao, M., et al. 1996. J Cell Biol. 135: 37-51. PMID: 8858161
- Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. | Borowsky, ML. and Hynes, RO. 1998. J Cell Biol. 143: 429-42. PMID: 9786953
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Layilin Antibody (C-7) | sc-377389 | 200 µg/ml | $322.00 | |||
Layilin Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-530018 | 200 µg Ab; 10 µg BP | $361.00 | |||
Layilin Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-523308 | 200 µg Ab, 40 µg BP | $361.00 | |||
Layilin Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-543820 | 200 µg Ab; 20 µg BP | $361.00 | |||
Layilin Antibody (C-7) AC | sc-377389 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Layilin Antibody (C-7) HRP | sc-377389 HRP | 200 µg/ml | $322.00 | |||
Layilin Antibody (C-7) FITC | sc-377389 FITC | 200 µg/ml | $336.00 | |||
Layilin Antibody (C-7) PE | sc-377389 PE | 200 µg/ml | $349.00 | |||
Layilin Antibody (C-7) Alexa Fluor® 488 | sc-377389 AF488 | 200 µg/ml | $364.00 | |||
Layilin Antibody (C-7) Alexa Fluor® 546 | sc-377389 AF546 | 200 µg/ml | $364.00 | |||
Layilin Antibody (C-7) Alexa Fluor® 594 | sc-377389 AF594 | 200 µg/ml | $364.00 | |||
Layilin Antibody (C-7) Alexa Fluor® 647 | sc-377389 AF647 | 200 µg/ml | $364.00 | |||
Layilin Antibody (C-7) Alexa Fluor® 680 | sc-377389 AF680 | 200 µg/ml | $364.00 | |||
Layilin Antibody (C-7) Alexa Fluor® 790 | sc-377389 AF790 | 200 µg/ml | $364.00 |