LARP4 Activators
Chemical activators of LARP4 include a variety of compounds that enhance its function in mRNA stabilization through different cellular mechanisms. Forskolin, by elevating cyclic AMP levels, directly increases the activity of adenylate cyclase, which in turn can boost the functional activity of LARP4 by promoting mRNA stabilization. This is facilitated through the interaction between LARP4 and mRNA, as LARP4's role includes the regulation of mRNA stability. Similarly, Ionomycin, by acting as a calcium ionophore, raises intracellular calcium levels that could enhance LARP4's interaction with the mRNA poly(A) tail, an interaction that is essential for the stability and integrity of mRNA molecules. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C, which can indirectly lead to the enhancement of LARP4's role in mRNA stabilization through the phosphorylation of associated factors. Okadaic Acid and Calyculin A, both phosphatase inhibitors, maintain proteins in a phosphorylated state, which can positively influence LARP4's interaction with mRNA by preventing the dephosphorylation of proteins involved in this process.
Anisomycin activates stress-activated protein kinases, leading to the phosphorylation of factors that regulate mRNA stability, thereby boosting LARP4's role under stress conditions. Hydrogen Peroxide, as an inducer of oxidative stress, can activate signaling pathways that regulate mRNA stability, thus engaging LARP4 in the cellular response to maintain mRNA integrity. Zinc Chloride can activate LARP4 by binding to it and influencing its RNA-binding activity, which is critical for its role in mRNA stabilization. Bisindolylmaleimide I, although a specific inhibitor of some protein kinase C isoforms, can lead to the activation of alternative pathways that enhance LARP4's function. Thapsigargin, by increasing cytosolic calcium levels through SERCA pump inhibition, can also activate LARP4 by inducing stress pathways that involve mRNA stabilization. Furthermore, 15-Deoxy-Delta(12,14)-prostaglandin J2 activates PPARγ, which may promote LARP4's interactions with mRNA stabilization complexes. Lastly, Spermidine enhances LARP4's interaction with mRNA, which is pivotal for the stability and translational efficiency of the mRNAs regulated by LARP4. Each of these chemicals, through their distinct mechanisms, can activate LARP4 and thereby play a role in the complex regulatory network of mRNA stability and processing within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates the enzyme adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can enhance the activity of LARP4 by promoting mRNA stabilization, as LARP4 is known to interact with mRNA and regulate its stability. Thus, by increasing cAMP, Forskolin can enhance the functional activity of LARP4 in its role in mRNA stabilization processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. Since LARP4 has been associated with the regulation of mRNA poly(A) tail length in response to cellular stress, which can be calcium-dependent, Ionomycin can activate LARP4 by enhancing its interaction with the mRNA poly(A) tail and stabilizing it, as a response to the increase in intracellular calcium. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate various substrates. While PKC's direct phosphorylation of LARP4 is not documented, PKC activation can lead to phosphorylation of factors associated with mRNA stabilization, thus enhancing the functional activity of LARP4 in mRNA stabilization and translation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases such as PP1 and PP2A, which results in increased phosphorylation levels of cellular proteins. As phosphorylation can regulate protein-protein interactions, the inhibition of dephosphorylation by Okadaic Acid could lead to an enhanced functional activity of LARP4 in its interaction with mRNA and associated stabilizing factors. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic Acid, Calyculin A is also a potent inhibitor of protein phosphatases like PP1 and PP2A. By inhibiting these phosphatases, Calyculin A could promote the phosphorylation state of proteins that interact with or regulate LARP4, leading to an increased functional activity of LARP4 in mRNA stabilization and processing. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases (SAPKs) which can influence mRNA metabolism. The activation of SAPKs can lead to the phosphorylation of factors that modulate mRNA stability, thereby enhancing the functional activity of LARP4 in its role of mRNA stabilization under stress conditions. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide induces oxidative stress, which can activate various signaling pathways, including those that regulate mRNA stability. The stress response pathways influenced by Hydrogen Peroxide can lead to the activation of LARP4 as it plays a role in maintaining mRNA stability under stress conditions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a cofactor for many enzymes and is known to influence RNA metabolism. Zinc Chloride can activate LARP4 by binding to regulatory domains that influence its RNA-binding activity, thus functionally activating LARP4's role in mRNA stabilization and translation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of certain PKC isoforms, leading to alterations in cellular signaling pathways. By inhibiting specific PKC isoforms, it may indirectly activate alternative pathways or kinases that enhance the functional activity of LARP4 in mRNA stabilization. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the SERCA pump, causing an increase in cytosolic calcium levels. Elevated calcium can activate pathways that modulate RNA-binding protein activity. Thapsigargin may activate LARP4 by inducing cellular stress pathways that LARP4 is part of, specifically enhancing its role in mRNA stabilization. | ||||||